大剂量呋塞米持续静脉泵入治疗早期急性肾损伤的疗效观察

The curative effect of high dose furosemide continuous infusion for the treatment of acute kidney injury

目的：观察分析大剂量呋塞米持续静脉泵入治疗早期急性肾损伤的临床效果。方法：选取2012年2月～2015年8月于我院进行常规呋塞米治疗无效的早期急性肾损伤患者80例,采用大剂量呋塞米持续静脉泵入治疗,观察分析治疗前后血肌酐、血钾、氧合指数水平变化、临床有效率和不良反应发生率。结果：患者血肌酐、血钾水平随着治疗时间不断下降,氧合指数随着治疗时间不断上升,不同时间段的差异比较有统计学意义（P〈0.05）;治疗有效率为88.75%;不良反应发生率为3.75%。结论：大剂量呋塞米持续静脉泵入治疗常规呋塞米治疗无效的早期急性肾损伤疗效显著,不良反应发生率低,值得临床推广。

Objective：To observe the analysis of high dose furosemide continuous infusion of clinical effect of early treatment of acute kidney injury. Methods：80 cases of early acute kidney injury patients which were invalid routine of furosemide in the treatment in our hospital from February 2012 to August 2015 were selected,Then use of high dose furosemide continuous infusion in the treatment,and the before and after treatment in patients with serum creatinine,serum potassium,oxygen synthetic index level changes and clinical efficiency and side effect incidence were observed and analysed. Results：After treatment,patients with serum creatinine,serum potassium levels decreased gradually with the treatment time,oxygenation index with increasing treatment time and different time difference compared with statistical significance（P 〈0.05）; patients treated with the effective rate was 88.75%; adverse reactions occurred rate was 3.75%. Conclusion： high dose furosemide continuous intravenous infusion of ineffective treatment routine of furosemide in the treatment of early acute renal injury effect significant,adverse reactions occur rate is low,it is worth for clinical use.