氟西汀合并奥氮平治疗抑郁症的临床疗效和安全性分析

Analysis of clinical efficacy and safety of fluoxetine combined with olanzapine in the treatment of depression

目的：观察分析氟西汀合并奥氮平治疗抑郁症的有效性和安全性。方法：选取我院2014年6月～2015年6月收治的90例抑郁症患者,运用双色球随机分组法分为观察组45例和对照组45例,对照组采用氟西汀治疗,观察组采用氟西汀合并奥氮平治疗,观察两组临床治疗效果。结果：观察组治疗总有效率75.55%,高于对照组的46.67%;观察组不良反应发生率20.00%,低于对照组的37.78%（P〈0.05）;治疗前两组HAMD评分无明显差异,治疗后观察组HAMD评分较对照组显著降低（P〈0.05）。结论：针对抑郁症,采用氟西汀合并奥氮平治疗,有利于缓解临床症状,提高治疗效果,不良反应少,安全性高,值得临床推广。

Objective：To probe into the effectiveness and safety of fluoxetine combined with olanzapine in the treatment of depression.Methods：90 patients with depression and who accepted treatments in our hospital from June,2014 to June,2015 were selected,and were divided into the observation group of 45 cases and the control group of 45 cases by the two color random grouping method.In the control group,they were treated with fluoxetine while in the observation group,they were treated with the fluoxetine combined with olanzapine. Then,the clinical treatment effects of two groups of patients were observed Outcome：The total effective rate in the observation group was 75.55%,which was higher than that in the control group of 46.67%;And the incidence rate of adverse reactions in the observation group was 20%,which lower than that in the control group of 37.78%（P〈0.05）;There was no significant difference in the HAMD score between the two groups before treatment. After treatment,the HAMD score of the patients in the observation group was significantly lower than that in the control group（P 〈0.05）. Conclusion：For the patients with depression,the treatment of fluoxetine combined with olanzapine which it is beneficial to alleviate clinical symptoms,improve the treatment effect,and the adverse reaction is little,safety is high,thus it is worth to be widely applied and promoted in clinical.