氟伐他汀与丁苯酞软胶囊联合治疗对急性脑梗死患者的影响

The effect of fluvastatin combined with butylphthalide soft capsules in the treatment of acute cerebral infarction

目的 探讨急性脑梗死病人进行丁苯酞软胶囊与氟伐他汀联合治疗的临床效果及对患者血清C反应蛋白的动态影响.方法 选取我院2013年6月-2014年5月急性脑梗死病人100例,根据随机数字表法分为研究组、对照组,每组50例,两组均进行血压控制、抗感染、脱水、营养脑细胞、降低颅压等常规疗法,研究组在此基础上进行丁苯酞软胶囊与氟伐他汀疗法,对照组仅服用氟伐他汀,两组均治疗2W,比较两组的临床效果;比较两组治疗前后的神经功能缺损程度评分量表（NIHSS）评分、Barthel指数评分、FMA评分情况;比较两组治疗前后的纤维蛋白原、红细胞压积等血液流变指标;比较两组治疗前、治疗后3d、治疗后1W、治疗后2W的血清C反应蛋白（CRP）水平的动态改变.结果 研究组的临床有效率为84.0％,对照组的临床有效率为52.0％,两组比较差异有统计学意义（P＜0.05）;治疗后,研究组神经功能缺损程度量表（NIHSS）评分情况显著优于对照组（P＜0.05）;研究组治疗后的Bar-thel指数评分、FMA评分情况显著优于对照组（P＜0.05）;治疗后研究组的纤维蛋白原、红细胞压积等血液流变指标显著优于对照组,差异有统计学意义（P＜0.05）;研究组治疗后3d、治疗后1W、治疗后2W的血清CRP水平优于对照组,差异有统计学意义（P＜0.05）.结论 对急性脑梗死病人进行丁苯酞软胶囊与氟伐他汀联合疗法,可显著改善病人的神经功能缺损程度,提高其日常生活能力,改善其血流动力学指标及血清C反应蛋白,临床效果确切,值得临床推广.

Objective To explore the effect of fluvastatin combined with butylphthalide soft capsules in the treatment of acute cerebral infarction and level of serum C reactive protein.Methods 100 acute cerebral infarction patients treated in our hospital from June 2013 to May 2014 were randomly divided into study group and control group,which 50 cases in each group,patients in both were treated with on blood pressure control,anti infection,dehydration,nutrition of brain cells to reduce the intracranial pressure.Patients in the study group were given butylphthalide soft capsules combined with fluorine atorvastatin therapy in addition to the treatment above.Patients in the control group were only treated with atorvastatin,patients were treated for 2 weeks.The clinical effects were compared between the two groups.National Institute of Health stroke scale score,Barthel index score,and FMA score before and after treatment in two groups were compared.The blood rheology index of fibrinogen and red blood cell were compared.The dynamic change of serum C ＆#183; reactive protein（CRP） levels in two groups were compared.Results The clinical effective rate of the study group was 84%,while 52% in the control group,the difference was statistically significant between the two groups （P 〈 0.05）.Mter treatment,the NIHSS scores were significantly better than the control group （P 〈 0.05）.The Barthel score and FMA scores were significantly higher than those in the control group（P 〈 0.05）;After treatment,the blood rheology indexes of the study group were significantly better than those of the control group（P 〈 0.05）;the serum CRP level in the study group was significantly better than that in the control group after 1 weeks,2 weeks treatment,and the difference was statistically significant （P 〈 0.05）.Conclusion Patients with acute cerebral infarction of butylphthalide soft capsules and fluorine of Atorvastatin Combined therapy can significantly improve the patient＆#39;s neurologic impairment and improve the ability of daily life,improve the hemodynamics and serum C reaction protein,have the clinical curative effect,worthy of clinical promotion.