干扰素治疗相关的自身免疫性副作用研究进展

Research progress of autoimmune side-effects associated with interferon treatment

干扰素（IFNs）是一种广泛存在的具有强烈抗病毒作用的细胞因子,IFN-α被认为是目前慢性乙型肝炎和丙型肝炎的标准治疗方法.病毒感染时,尤其是丙型肝炎病毒（HCV）感染,包含核酸的免疫复合物诱导的IFN-α产生增加,持续性的免疫系统激活诱导自身免疫性损伤.IFN为基础的治疗可以加重这种自身免疫损伤.IFNs可以影响多种类型的细胞,使多个系统受到影响.因此,用IFN-α治疗的患者可以出现广谱的自身免疫性疾病,如自身免疫性甲状腺、风湿性关节炎、冷球蛋白血症、结节病、系统性红斑狼疮、1型糖尿病和重症肌无力等.

Intefferons （IFNs） are ubiquitous cytokines with strong antiviral activities.IFN-α is the standard treatment for chronic hepatitis B and hepatitis C.Upon virus infection,particular hepatitis C virus （HCV） infection,immune-complexes containing HCV RNA induce the overproduction of IFN-α and sustained immune activation which lead to autoimmune tissue damage.IFN based therapy may exacerbate the autoimmune injury.IFNs may affect a wide array of cell types and result in wide systemic effects.Therefore,IFN based therapy contributes to the pathogenesis of broad-spectrum autoimmune diseases,such as autoimmune thyroiditis rheumatoid arthritis,cryoglobulinemia,sarcoidosis,systemic lupus erythematosus （SLE）,type 1 diabetes mellitus,and myasthenia gravis.