巨噬细胞极化与肥胖型哮喘

Macrophages polarization and obesity asthma

肥胖和支气管哮喘（简称哮喘）之间的相关性日益受到关注，大量研究证明两者之间存在关联，但是其机制尚不明确。肥胖导致机体产生的慢性低度炎症，可能是解释肥胖和哮喘关联性的因素之一。研究证明，脂肪组织中浸润的免疫细胞和炎症细胞，释放细胞因子，诱发炎症反应，损害肺、肝、心脏等其他终末器官，并引发慢性疾病如哮喘、脂肪肝、冠心病等。其中，巨噬细胞是比较重要的免疫细胞。通过巨噬细胞介导的炎症反应解释肥胖与哮喘之间的关系不容忽视。本文就巨噬细胞及其亚型特点作一综述，并阐述其与肥胖和哮喘的关联。

Recently investigators pay more attention to the relationship between obesity and bronchial asthma （asthma）. A large literatures suggest the association between obesity and asthma. But the mechanism about this association is not fully clarified. Chronic low grade systemic inflammation is recognized as the characteristic of obesity which may possibly explain the relationship between obesity and asthma. There is now a great deal of research for infiltration of immune and inflammatory cells into adipose tissue that leads to inflammatory cytokines that release and subsequently lead to organ damage such as pulmonary, liver and heart. This process may cause chronic diseases such as asthma, fatty liver disease and coronary heart disease. Macrophages are the key immune cells. We can not ignore the maerophage-mediated inflammatory that may explain the mechanism. This review focused on the effect of macrophages and its subtypes in obesity and asthma. Also, it explored the relationship between obesity and asthma.