妊娠期妇女糖耐量试验血糖水平对大于胎龄儿的影响

Glucose level of oral glucose tolerance test is associated with the occurrence of large for gestational age infants

探讨妊娠期妇女24．28周75g口服葡萄糖耐量试验（OGTT）血糖水平对大于胎龄儿（LGA）的影响。连续入选2014年1月至8月于济宁医学院附属医院例行产检且诊断为妊娠期糖尿病（GDM）者790例，糖耐量正常（NGT）者478名，追踪随访至其分娩，收集子代出生体重等指标。选取单胎活产的GDM患者及NGT者．分析影响子代出生体重的危险因素。GDM组分娩LGA的几率显著高于NGT组（47．30％对31．30％，P〈0．05）；校正混杂因素后发现75gOGTT试验2h血糖是LGA的独立危险因素，且75gOGTT试验2h血糖每增加1mmoL／L，LGA的发生风险增加约29％（OR=1．29，95％C11．05～1．58，P=0．02）。妊娠期75g0GTT2h血糖水平是LGA的独立危险因素。

To explore the influence of glucose level of 75 g oral glucose tolerance test （ OGTT ） druing pregnancy on delivery of large for gestational age infants. This research selected 790 cases of patients diagnosed as gestational diabetes mellitus（ GDM） , 478 cases of pregnant women diagnosed as normal glucose tolerance（ NGT） from Affiliated Hospital of Jining Medical University in 2014 and followed up until they delivered. Single live births were selected, risk factors which had influence on offsprings, birth weight were analysed. GDM group had significantly higher rate of delivering large for gestational age（LGA）infants than that of NGT group（47. 30% vs 31. 30%, P〈0. 05）. Adjusting for confounding factors, it suggested that 2 h plasma glucose level of 75 g OGTT was an independent risk factor for the delivery of LGA infants, and 1 mmol/L glucose increment in 75 g OGTT 2 h plasma glucose level, mayincreasetheriskofLGAby29%（OR=1.29,95%CI1.05-1.58,P=0.02）. The2hplasmaglucoselevelof75 g OGTT is an independent risk factor for delivery of LGA infants.