血清肿瘤标志物CA19-9和CA125在胆管癌诊断中的价值

The Clinical Value of Serum CA19-9 and CA125 in Diagnosing of Cholangiocarcinoma

目的:探讨肿瘤标志物CA19-9和CA125在胆管癌诊断中的价值。方法:回顾性分析105例胆管癌患者CA19-9和CA125血清学水平,通过ROC曲线分析等探讨CA19-9和CA125在胆管癌中的价值进行评估。结果:CA19-9和CA125在胆管癌患者中明显升高;ROC曲线示:CA19-9诊断界值为73.25U/ml,敏感性和特异性分别为69.3%和87.7,CA125诊断界值为10.60 U/ml,敏感性和特异性分别为72.5%和60.0%,两者联合诊断的敏感性和特异性分别为87.6%和53.8%。结论:CA19-9和CA125在胆管癌的诊断和TNM分期中具有较大的临床价值,且CA19-9有更高的特异性和诊断效能。

Objective ： To explore the clinical value of serum CA19-9 and CA125 in diagnosing of cholangiocarcinoma. Methods ： Retrospective analysis was carried out and the serum of CA19-9, CA125 were measured preoperative in 154 cholangiocarcinoma patients. Receiver operator characteristic curves of tumor markers were conducted to explore the value of serum CA19-9 and CA125 in diagnosing of cholangiocarcinoma. Result ：Elevated tumor markers levels were found in malignancy; the two tumor markers on the TNM staging of cholangiocarcinoma were statistically significant. The cutoff of CA19-9 was 73.25 U / ml（sensitivity,69.30%; specificity,87.7%）, the CA125 was 10.60 U / ml（sensitivity, 72.5%; specificity,60.0%）; the sensitivity and specificity to combined of CA19-9 and CA125 was 87.6% and 53.8%. Conclusions ： Serum CA19-9 and CA125 play an important role in the diagnosing and TNM staging of cholangiocarcinoma; CA19-9 has higher specificity and super diagnosis value than CA125, and provides an important way for the diagnosing of cholangiocarcinoma.