胰岛素强化治疗对早期糖尿病肾病的临床疗效分析

Clinical Efficacy of Intensive Insulin Therapy in the Treatment of Early Diabetic Nephropathy

目的:评估胰岛素强化治疗对早期糖尿病肾病的临床疗效。方法:选择2012年1月至2015年6月收治我科的早期糖尿病肾病患者94例,随机分为试验组和对照组。试验组(47例)给予胰岛素强化治疗,对照组(47例)应用口服降糖药治疗。比较两组治疗前和治疗30天后,患者空腹血糖、餐后血糖、糖化血红蛋白、尿蛋白排泄率、β_2微球蛋白和血肌酐的变化。结果:两组患者治疗后FBG、2h PBG、HbA1c、UAER及β_2-MG均显著降低,组内差异有统计学意义(P<0.05)。治疗后两组间比较,FBG、2h PBG、HbA1c差异无统计学意义(P>0.05),而UAER及β_2-MG差异有统计学意义(P<0.05)。结论 :应用胰岛素强化治疗早期糖尿病肾病,临床疗效确切,能有效控制血糖水平,改善肾功能,延缓糖尿病肾病的进展。

Objective ： To investigate the clinical efficacy of intensive insulin therapy in the treatment of early diabetic nephropathy. Methods ： A total of 94 patients suffered from early diabetic nephropathy were selected and divided into the experiment group（n =47） and the control group（n =47）. The patients in the experiment group were performed by intensive insulin therapy,and the other patients in the control group were treated with oral hypoglycemic agents. Level of FBG, 2PBG, HbA1c, UAER,β_2-MG and SCr were compared and statistically analyzed before and after treatment in the two groups. Results ： After the treatment, the level of FBG 、2h PBG、HbA1c 、UAER 、β2-MG and SCr decreased, and the difference was statistically significant（P〈0.05）. the level of FBG 、2h PBG 、HbA1c show no statistical difference between two groups（P〉 0.05）. However, the difference in level of UAER and β_2-MG was statistically significant（P 〈0.05）. Conclusion ： The intensive insulin therapy in the treatment of early diabetic nephropathy has definitely clinical curative effect,it can control blood sugar levels, improve the renal function and delay the progress of diabetic nephropathy.