台山地区妊娠期血清特异甲状腺指标参考值的探讨

Reference Value of Serum Thyroid Specific Index in Taishan Area

目的:探讨台山地区正常孕妇早、中、晚孕期的促甲状腺素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)参考区间。方法:对非妊娠215例、孕期210例的健康妇女进行甲状腺功能检测,以建立不同孕期甲状腺功能三项指标的正常参考区间。结果:TSH在早孕期(T1)[1.13(0.10-3.45)m IU/ml]有所下降,从中孕期(T2)[1.35(0.22-3.79)m IU/ml]开始逐渐回升,至晚孕期(T3)[2.18(0.68-4.96)m IU/ml]逐渐接近正常非孕人群的水平,各期水平均有明显差异(P<0.01);FT4和FT3均从早孕期就开始进行性下降,并持续整个孕程,各期水平均有明显差异(P<0.01)。结论:临床医生可根据此参考值诊断台山地区孕期甲状腺激素功能异常,早期诊断并采取有效干预措施,避免不良妊娠结局,保障母婴安全。

Objective ：To study the Taishan area normal pregnant women early,middle and late pregnancy thyrotropin（TSH）, free thyroxine（FT4）, three free triiodothyronine（FT3） reference interval. Method ：The three thyroid function in nonpregnant 215 cases, 210 cases of early pregnancy（T1）,215 cases the middle pregnancy（T2）,246 cases of late pregnancy（T3）was examined to establish the normal reference interval of thyroid function during pregnancy. Results ： TSH declined at T1（1.13 m IU / ml）,rised gradually from T2（ 1.35 m IU / ml） and moved closer to normal levels of production of non-pregnant population at T3（ 2.18 m IU / ml）,P 〈0.01. FT4 and FT3 decreased gradually from T1 to T3 P〈 0.01. Conclusion ： The clinician may diagnose and effectively treat early to avoid adverse pregnancy outcomes and guarantee safe motherhood based on the normal reference interval of thyroid function during pregnancy.