布地奈德联合盐酸氨溴索雾化吸入治疗小儿毛细支气管炎疗效观察

Effect of aerosol inhalation of budesonide combined with ambroxol hydrochloride in the treatment of children with bronchiolitis

目的:探讨布地奈德联合盐酸氨溴索雾化吸入治疗小儿毛细支气管炎的临床疗效和安全性。方法:选择110例小儿毛细支气管炎患儿,将其平均分为对照组和观察组各55例,两组患儿均进行抗感染、祛痰、止咳、平喘、吸氧对症等常规治疗,观察组患儿在常规治疗的基础上加布地奈德联合盐酸氨溴索雾化吸入治疗。比较两组患儿治疗后的主要临床症状体征消失时间、临床疗效以及不良反应的发生情况。结果:组患儿临床症状体征消失时间明显少于对照组,观察组患儿治疗总有效率为96.36%高于对照组的83.63%,差异有统计学意义(P<0.05)。两组患儿均无药物不良反应发生。结论:布地奈德联合盐酸氨溴索雾化吸入治疗小儿毛细支气管炎的临床疗效确切,安全性好,值得临床应用。

Objective： To discuss the effect and safety of aerosol inhalation of budesonide combined with ambroxol hydrochloride on children bronchiolitis. Methods： 110 cases of children bronehiolitis were equally divided into the control group and observation group. Both groups underwent such conventional treatment as anti-infection, loosening phlegm, relieving asthma and oxygen uptake, while the observation group received additional aerosol inhalation of budesonide combined with ambroxol hydrochloride on the basis of conventional treatment. Then, the disappeared time of the main clinical symptoms and signs, clinical effect and the incidence of adverse reactions of patients in both groups were evaluated. Results The disappeared time of the main clinical symptoms and signs of patients in the observation group was significantly lower, and the total effective rate was 96.36%, higher than 83.63% in the control group, which were of statistical differences （P 〈 0.05）. And there was no adverse reactions for children in both groups. Conclusion： Aerosol inhalation of budesonide combined with ambroxol hydrochloride is effective in treating children with bronchiolitis, it is safe and worthy of clinical application.