复方妥英麻黄茶碱片致共济失调和口面部不自主运动

Ataxia and orofacial involuntary movement due to compound phenytoin sodium

1例63岁、有10年慢性阻塞性肺疾病史的女性患者从2013年1月至2015年1月口服复方妥英麻黄茶碱片2片，3次/ d。2014年4月（用药16个月）首次出现步行不能、面部不自主运动，至2015年1月共发作4次。考虑为复方妥英麻黄茶碱片所致共济失调，立即停用复方妥英麻黄茶碱片，静脉滴注注射用复合辅酶400 U、1次/ d。12 d 后患者可独自行走，无明显面部不自主运动并出院。出院后2个月随访，患者病情无反复，可独立步行，日常生活恢复正常。

A 63-year-old woman with chronic obstructive pulmonary disease for 10 years received compound phenytoin sodium（2 tablets,three times daily）from January 2013 to January 2015. The patient developed a paroxysmal dysbasia and facial involuntary movement in April 2014 （ 16 months after medication）and 4 times outbreaking from April 2014 to January 2015. She was considered the dystaxia due to compound phenytoin sodium. Compound phenytoin sodium was stopped immediately and an IV infusion of coenzyme complex injection 400 U once daily was given. Twelve days later,the patient could walk alone without obvious involuntary movement in her face. Then she was discharged. The result of follow-up 2 months after discharge showed that the symptoms had no recurrence,and the patient could walk alone. Her daily life returned to normal.