鱼白桑止咳方治疗慢性支气管炎患者128例疗效观察

Clinical observation of Yubaisang-Zhikefang decoction on treating 128 patients withchronic bronchitis

目的：评价鱼白桑止咳方对慢性支气管炎（chronic bronchitis, CB）急性发作患者的临床疗效。方法将符合入选标准的128例CB急性发作患者按随机数字表法分为2组，对照组63例采用西医常规疗法治疗，治疗组在对照组基础上加服鱼白桑止咳方。均治疗7 d。观察2组治疗前后症状、体征及影像学变化，记录化验室指标的改变，评价临床疗效。结果治疗组总有效率[92.58%（60/65）比79.37%（50/63）]，高于对照组（χ2＝4.434，P＝0.035）。治疗组止咳时间[（3.28±1.21）d比（5.77±1.45）d， t＝10.562]、平喘时间[（8.02±3.29）d比（10.83±7.17）d，t＝2.864]、痰液恢复正常时间[（3.27±1.18）d比（5.18±1.16）d，t＝9.232]、肺部啰音消失时间[（4.53±1.27）d比（7.96±1.45）d，t＝14.249]均较对照组缩短（P＜0.05）。治疗后，治疗组 WBC[（5.9±2.7）×109/L 比（8.1±2.6）×109/L，t＝4.693]、中性粒细胞计数[（63.3±6.1）%比（69.2±6.5）%，t＝5.297]、CRP[（14.5±5.9）mg/L比（18.4±4.8）mg/L，t＝4.095]均低于对照组（P＜0.05）。结论鱼白桑止咳方加减配合西医常规疗法，可提高CB急性发作患者总体疗效，缓解临床症状，缩短病程，疗效优于单纯西医常规疗法。

Objective To observe effects of theYubaisang-Zhikefangdecoction on chronic bronchitis.MethodsA total of 128 patients were randomly divided into two groups. The control group was given the conventional therapy, and the treatment group was added theYubaisang-Zhikefang decoction based on the conventional therapy.ResultsThe total effective rate of treatment group was significantly better than the control group （92.58%vs. 79.37%;χ2=4.434,P=0.035）. The treatment group significantly improved the symptoms of time of cough disappearance（3.28 ± 1.21 d vs. 5.77 ± 1.45 d;t=10.562,P〈0.05）, time of asthma stop （8.02 ± 3.29d vs. 10.83 ± 7.17 d;t=2.864,P〈0.05）, time of sputum disappearance （3.27 ± 1.18d vs. 5.18 ± 1.16 d;t=9.232,P〈0.05）, time of moist sounds disappearance（4.53 ± 1.27 vs. 7.96 ± 1.45 d;t=14.249, P〈0.05）. And the treatment group significantly improved the results of blood tests and lung imaging, like the WBC （5.9×109/L ± 2.7×109/L vs. 8.1×109/L ± 2.6×109/L;t=4.693,P〈0.05）, N% （63.3% ± 6.1% vs. 69.2% ± 6.5%;t=-4.68,P〈0.05）, CRP （14.5 ± 5.9 mg/L vs. 18.4 ± 4.8 mg/L;t=5.297,P〈0.05）.ConclusionThe integrated treatment ofYubaisang-Zhikefangdecoction plus convertional the rapy showed good effects on the patients with chronic bronchitis.