血清S100B蛋白水平对子痫前期患者的临床意义研究

Clinical Significance of Serum S100B Level in Preeclampsia Patients

目的探讨血清S100B蛋白水平对子痫前期患者的临床意义。方法选取2014年11月—2015年10月在深圳市宝安区妇幼保健院住院治疗的子痫前期患者60例,根据疾病严重程度分为轻度子痫前期组30例和重度子痫前期组30例;另选取同时期在本院进行产检的健康孕妇30例,作为对照组;同时纳入本院同期子痫患者1例。分别于入院时和分娩后3、7 d,检测受试者的血清S100B蛋白水平。结果 3组年龄比较,差异无统计学意义(P>0.05);重度子痫前期组入院孕周、分娩孕周短于对照组和轻度子痫前期组,差异有统计学意义(P<0.05)。3组血清S100B蛋白水平比较,差异有统计学意义(P<0.05);不同时间点比较,差异有统计学意义(P<0.05);患病情况与时间在血清S100B蛋白水平上存在交互作用(P<0.05)。其中,入院时、分娩后3 d,重度子痫前期组血清S100B蛋白水平高于轻度子痫前期组,轻度子痫前期组高于对照组,差异有统计学意义(P<0.05);分娩后7 d,3组血清S100B蛋白水平比较,差异无统计学意义(P>0.05)。入院时和分娩后3、7 d,子痫患者的血清S100B蛋白水平分别为0.170、0.090、0.053μg/L。结论血清S100B蛋白水平的变化提示脑血管参与了子痫前期的病理生理过程,其可能是子痫前期患者病情严重程度的判断指标和预测子痫发生的生物标志物之一。

Objective To investigate the clinical significance of serum S100B level in preeclampsia patients. Methods From November 2014 to October 2015, we enrolled 60 preeclampsia patients who received hospitalized treatment in Maternal and Child Health Hospital of Baoan in Shenzhen. According to severity, we divided the patients into mild preeclampsia group （ n =30） and severe preeelampsia group （n = 30） . We also enrolled 30 healthy pregnant women who received antenatal care as control group and one eclampsia patient from the hospital in the same period. At admission, and 3 and 7 days after delivery, serum SIOOB level of the subjects was detected. Results The three groups were not significantly different in age （ P 〉 0. 05 ） ; severe preeclampsia group had shorter hospital gestational weeks at admission and shorter gestational weeks at delivery than control group and mild preeclampsia group （P 〈 0. 05 ） . There were significant differences in serum SIOOB level among the three groups and among different time points （P 〈 0. 05 ） ; there was interaction between severity and time points on serum S100B level （P 〈 0.05 ）; at admission and 3 days after delivery, the serum slOOB level of severe preeclampsia group was higher than mild preeclampsia group （ P 〈 0. 05 ）, and mild preeclampsia group was higher than control group （ P 〈 0. 05 ） ; 7 days after delivery, the three groups were not significantly different in serum S100B level （P 〉 0. 05） . At admission and 3 and 7 days after delivery, the serum SIOOB level of the preeclampsia patient was 0. 170, 0. 090 and 0. 053 μg/L Conclusion The change of serum SIOOB levels suggest that blood vessels of brain participate the pathophysiological process of preeclampsia, and it may be one of the indicators for disease severity and the occurrence of eclampsia.