CuBr_2作用下4-溴代亚甲基-2-喹啉酮的制备

Synthesis of 4-bromomethylene-2-quinolinone Assisted by CuBr_2

喹啉酮类衍生物具有重要的生理活性和药用价值,其合成方法引起众多化学工作者的广泛关注。本文从3-环戊烷基-N-烷基乙酰乙酰芳胺出发,在等化学计量的溴化铜作用下,实现分子内的环化和卤代反应,以88%的产率一步构建4-溴代亚甲基-2-喹啉酮化合物,并对其结构进行核磁和红外光谱表征。通过改变温度和溶剂等实验,确定最佳反应条件。

The quinolinone derivants are a class of important compounds with biological activities and medical values,therefore,many chemical workers paid attention to their preparation methods.4-bromomethylene-2-quinolinone was synthesized starting from 3-cyclopentane-N-alkyl-acetoacetanilide through intramolecular cyclization and halogenation with the assistant of CuBr_2 in 88% yield.The final product was characterized by NMR and IR spectra.Many experiments were operated to optimize reaction conditions by changing temperature and solvents.