磁共振T2 map成像对不同ARCO分期股骨头软骨变性的评估价值

Quantitative T2 Map of Cartilage in Different ARCO Stage of Femoral Head Necrosis

目的测量正常及不同ARCO分期条件下坏死股骨头软骨T2 map值的变化,评估其临床应用价值。方法搜集不同ARCO分期坏死股骨头(ARCOI期、ARCOII期、ARCOIII期)及正常股骨头各20例,年龄20-50岁,所有病例均行MRI检查。测量各期坏死及正常股骨头软骨的T2 map值的定量学数据。所有选取坏死及正常研究对象均排除骨质疏松及其他影响观察的基础性疾病。结果随着病情进展,坏死股骨头ARCO分期越高,软骨T2 map值越高,软骨的损害也就越明显;经LSD检验分析提示坏死股骨头ARCOIII期软骨与正常股骨头、ARCOI期、ARCOII期软骨T2 map值之间的差异有统计学意义,P值小于0.05。结论正常股骨头软骨的T2 map的数值大约可界定为(49.39±8.158)之间,临床上可将此区间值作为可能性参考标准;随着股骨头坏死病程的进展,股骨头软骨损伤变性的程度有逐渐加重趋势。

Objective To investigate the values of quantitative parameters of T2 map of cartilage in different ARCO stage of the femoral head necrosis.Methods Different Arco stage avascular necrosis of the femoral head （ARCO I, ARCOII, ARCOIII period） and normal femoral head with 20 cases in each were enrolled in this study from age 20 to50, all case of illness all MRI check. Data quantitative calculation of each period of femoral head necrosis and normal cartilage of femoral head T2 map value. All the selected necrosis and normal subjects were excluded on the basis of observation of disease osteoporosis and other effects.Results Along with the progress of the disease, avascular necrosis of the femoral head ARCO stage is high, the more serious illness, cartilage T2 map value higher, cartilage damage and also more obvious.The LSD test analysis showed that between avascular necrosis of the femoral head ARCOIII period cartilage and normal femoral head, ARCOI, ARCOII period cartilage T2 map values had significant difference, P values less than 0.05.Conclusion Normal T2 map values of the cartilage of the femoral head can be defined as about （49.39±8.158）, the clinical possibility can be the interval value as the reference standard, as with the progress of the ARCO I-III, the extent of the femoral head cartilage damage degeneration has a gradually increasing trend.