颅脑创伤患者血浆中类胰蛋白酶含量测定的临床意义

The expression of the tryptase in the plasma of the brain traumatic patients

目的：通过测定颅脑创伤患者血浆中类胰蛋白酶的含量变化，探讨类胰蛋白酶检测对颅脑创伤患者病情评估的意义。方法选择40例颅脑创伤患者作为观察组，20例健康人作为对照组，采用荧光酶联免疫法，利用过敏原自动检测仪测定样本血浆中类胰蛋白酶的含量。结果对照组血浆类胰蛋白酶含量为（2．97±1．05）μg／L，观察组血浆类胰蛋白酶含量（3．03±1．39）μg／L，与对照组比较差异无统计学意义；但重型颅脑创伤患者类胰蛋白酶含量（3．84±0．52）μg／L，与对照组比较差异有统计学意义（t ＝3．32，P ＜0．05）。重型颅脑创伤组内4例死亡患者的类胰蛋白酶含量（5．85±1．05）μg／L，明显高于重型颅脑创伤组内16例伤后2个月仍然存活患者的血浆类胰蛋白酶含量（2．49±0．52）μg／L，差异有统计学意义（t ＝8．13，P ＜0．01）。结论重型颅脑创伤患者血浆类胰蛋白酶含量明显增高，血浆类胰蛋白酶含量测定对颅脑创伤患者病情评估及预后判断有帮助。

Objective To detect the expression of the tryptase in the plasma,and study the meaning in brain traumatic patients.Methods There were two groups：the brain traumatic group（40 patients）and the control group （20 health people）.The content of plasma tryptase was determined by fluorescence enzyme immunoassay..Results The level of plasma tryptase had no statistical significance in control group（2.97 ±1.05）μg/L compared with the brain traumatic group（3.03 ±1.39）μg/L,however there had statistical significance comparing with sever brain traumatic patients（3.84 ±0.52μg/L）（t =3.32,P 〈0.05）.4 cases of death in patients with severe head injury group content of tryptase （5.85 ±1.05）μg/L,which was significantly higher than the group of 16 cases of injury in severe head injury after 2 months still alive with the content of serum tryptase （2.49 ±0.52）μg/L,the difference was statistically significant （t =8.13,P 〈0.01）.Conclusion The plasma tryptase level in sever brain traumatic patients increased significantly,and might be of importance for treatment strategies and prognosis.