猪肺磷脂注射液联合呼吸机鼻塞式持续正压通气治疗新生儿呼吸窘迫综合征的临床观察

Clinical observation of poractant alfa injection combined with nasal continuous positive airway pressure in the treatment of premature infants with respiratory distress syndrome

目的：观察猪肺磷脂注射液（固尔苏）联合呼吸机鼻塞式持续正压通气（CPAP）治疗新生儿呼吸窘迫综合征（NRDS）的临床效果。方法50例 NRDS 患儿按照治疗方式分为观察组25例（固尔苏联合采用 CPAP）及对照组25例（采用 CPAP），比较两组在治疗总有效率和动脉血气指标的差异。结果治疗组总有效率（88％）高于对照组（56％），差异有统计学意义（χ2＝4．861，P ＜0．05）；观察组治疗后动脉血气各指标均较治疗前有明显改善，差异均有统计学意义（均 P ＜0．05）；对照组早产儿治疗后动脉血气各指标均较治疗前有明显改善，差异均有统计学意义（均 P ＜0．05）。观察组治疗后 pH 值、PaO2和 PaCO2与对照组比较，差异均有统计学意义（t ＝6．00、8．49、4．46，均 P ＜0．05）。结论固尔苏联合呼吸机鼻塞式 CPAP 治疗 NRDS 优于单独使用呼吸机鼻塞式 CPAP。

Objective To observe the clinical effect of poractant alfa injection（curosurf）combined with nasal continuous positive airway pressure（CPAP）in the treatment of neonatal respiratory distress syndrome（NRDS）. Methods Fifty patients of infants with NRDS were divided into 25 cases of observation group（curosurf combined with CPAP）and 25 cases of control group（CPAP）according to the methods of the treatment.The differences in treatment efficacy rate and arterial blood gas index were compared.Results The efficacy rate of the observation group （88%）was higher than that of the control group（56%）,the difference between the two groups was statistically significant（χ2 =4.861,P 〈0.05 ）.After the treatment,the arterial blood gas index of the observation group were improved obviously compared with that before the treatment,the differences were statistically significant（all P 〈0.05）.After the treatment,the arterial blood gas index of the control group were improved obviously compared with that before the treatment,the differences were statistically significant（all P 〈0.05）.After treatment,the differences in pH value,PaO2 and PaCO2 of the observation group were statistically significant compared with the control group（t =6.00,8.49,4.46,all P 〈0.05）.Conclusion Poractant alfa injection combined with nasal CPAP in the treatment of NRDS is better than using CPAP alone.