晚期鼻咽癌洛铂结合同步化疗的临床观察

The clinical observation of lobaplatin combined with chemotherapy in the treatment of advanced nasopharyngeal carcinoma

目的探讨晚期鼻咽癌洛铂结合同步化疗的临床效果。方法 2010年8月到2014年12月诊治的晚期鼻咽癌患者94例,据随机抽签原则分为观察组与对照组,各47例。对照组给予常规化疗方案治疗,观察组在对照组治疗的基础上给予洛铂同步化疗治疗,每3周为1个周期,治疗观察3个周期。观察两组临床疗效、毒性反应情况、总生存时间与无进展生存时间。结果治疗后观察组与对照组的有效率分别为87.2%和57.4%,观察组的近期疗效明显高于对照组(P<0.05)。治疗期间观察组的血液系统异常、胃肠道反应、黏膜反应、肝肾功能异常等毒性反应发生情况与程度均明显好于对照组(P<0.05)。观察组的总生存时间与无进展生存时间分别为57.33±2.34个月与43.24±3.15个月,均明显多于对照组的45.25±4.19个月与37.25±3.90个月(P<0.05)。结论晚期鼻咽癌洛铂结合同步化疗能提高近期疗效,减少毒性反应的发生,从而延长远期生存时间。

Objective To explore the clinical effects of lobaplatin combined with chemotherapy in the treatment of advanced nasoph^geal carcinoma. Methods From August 2010 to December 2014 in our hospital, 94 advanced nasopharyngeal carcinoma patients, accorded to theprinciple of random draw, were equally divided into the observation group and control group （47 patients in each group）. The control group weretreated with conventional chemotherapy treatment, and the observation group were given the lobaplatin combined with chemotherapy. Every 3 weeksfor a period, all patients were treated 3 periods. Clinical efficacy, toxicity, the overall survival and progression - free survival time were observed.Results After treatment, the response rates in the observation group and control group were 87. 2% and 57. 4% respectively, and the observationgroup was significantly higher than that in the control group （ P 〈0. 05）. The situation and the extent of blood abnormalities, gastrointestinal toxicity, mucositis, liver and kidney dysfunction, etc in the observation group during treatment were significantly better than those of the control group（ P 〈0. 05）. The overall survival time and the progression - free survival time in the observation group （57.33 ± 2. 34 months and 43.24 ± 3. 15months） were significantly higher than that in the control group （45？ 25 ± 4.19 months and 37. 25 ± 3.90 months） （ P 〈 0.05）. ConclusionThe lobaplatin combined with chemotherapy in the treatment of advanced nasopharyngeal carcinoma can improve the short - term effect, reduce theincidence of adverse reactions, thereby extend the long - term survival time.