中短程低剂量吸入糖皮质激素对哮喘儿童生长的影响

Efficacy of short-medium term and low-dose inhalation of corticosteroids in treatment of asthma and its effect on growth in children

目的：探讨中短程低剂量持续吸入糖皮质激素（ICS）对哮喘儿童身高及体质量的影响。方法：观察64例5～14岁中重度持续哮喘儿童经布地奈德福莫特罗治疗前、治疗12周、24周及52周后的身高、体质量及肺功能值并计算生长速率及体质量指数，同54例正常对照组儿童进行比较。结果：哮喘儿童生长速率及体质量指数在治疗后12、24周及52周后同正常对照组相比均无统计学意义（P〉0．05），肺功能较治疗前改善明显。结论：中短程低剂量持续ICS治疗对哮喘儿童生长速率及体质量指数无明显抑制，且能有效改善哮喘儿童肺功能。

Objective： To observe the efficacy of short-medium term and low dose inhalation of corticosteroids （ICS） in the treatment of bronchial asthma as well as its effect on growth and development in children. Methods：A total of 64 children diagnosed with bronchial asthma were assigned to treatment and 54 normal children were control group. Comparisons of main pulmonary function indicators, growth velocity （GV） and body mass index （BMI） between the two groups were carried out before treatment and at 12, 24 and 52 weeks after treatment. Results：At 12, 24 and 52 weeks after the treatment, the asthma group significantly increased pulmonary function indicators （P〈0.05）. The GV and BMI showed no significant differences between the two groups atl2, 24 and 52 weeks after treatment （P〉0.05）. Conclusion： Low dose ICS for one year may have no marked effect on the growth and development of children with asthma, and could enhance pulmonary function in those children.