摘要
随着现代药物递送系统的发展,甘油三酯(triacylglycerols,TAGs)类脂质辅料在药物制剂中的应用日益广泛。由于TAGs的性质与其结构组成具有重要联系,为指导TAGs类药用辅料的应用,应对其进行严格的质量控制,然而,TAGs组成复杂使得有效分析手段缺失。笔者对TAGs分离分析常用的薄层色谱法、固相萃取法、气相色谱法、液相色谱法和二维液相色谱法以及超高效合相色谱法等进行了较为全面的综述,比较了各技术的优缺点和适用范围;并结合自身研究认为超高效合相色谱是TAGs最有效的分析方法之一。
As one kind of lipid exeipients, triacylglycerols (TAGs) are being more and more widely used in pharmaceutics with the development of advanced drug delivery systems. As their characteristics are mainly determined by their structures and compositions, strict quality control ought to be performed on TAGs, in order to guide their use in pharmaceutics. However, be- cause of their complex compositions, no qualtity standard is set for TAGs in Ch. P currently. In this paper, we reviewed the meth- ods for the separation and analysis of TAGs, includingthin-layer chromatography, solid-phase extraction, gas chromotography, liquid chromatography, two-dimensional liquid chromatography, and ultraperformance convergence chromatography, and summa- rized their advantages and disadvantages. The application scope of each method was also overviewed in this review. Besides that we also pointed outthat according to our own study the newly emerged ultraperformance convergence chromatography would be one of the best methods to analyze TAGs.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2016年第14期1224-1229,共6页
Chinese Pharmaceutical Journal
基金
国家科技重大专项重大新药创制资助项目(2015ZX09303001)
关键词
甘油三酯
分离分析
二维液相色谱
超高效合相色谱
triacylglycerols
separation and analysis
two dimensional liquid chromatography
ultrapefformance convergence chroma-tography