基于关联规则和复杂系统熵聚类的郭蓉娟治疗失眠“昼夜两方”用药规律研究

An analysis of TCM master Guo Rongjuan's medication rule for treating insomnia based on association rules and complex systems clustering algorithm

目的:基于中医传承辅助系统(V2.5)软件,探讨郭蓉娟教授治疗失眠的用药规律与经验。方法:收集郭蓉娟教授门诊治疗失眠的病案,录入"中医传承辅助系统",采用改进互信息法、复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘方法,明确处方中各药物的使用频次及药物之间的关联规则,分析郭蓉娟教授治疗失眠的用药经验。结果:对筛选出的206首处方进行分析,确定处方中药物的使用频次,药物之间的关联规则,挖掘出16个核心组合和8首新处方。结论:郭蓉娟教授治疗失眠多用柔肝滋肾、疏肝清肝之品。

Objective： To analyze the medication rule and experience of Professor Guo Rongjuan for insomnia through TCM inheritance support system（V2-5）- Methods： Prescriptions for insomnia were collected, sorted and entered into the TCM inheritance system（V2-5） to analyze the composition principles by the methods of revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster- Results： By analyzing 206 prescriptions, the frequency of each herb included in the database was computed; 16 core combinations and 8 new prescriptions were mined from the database- Conclusion： Professor Guo Rongjuan is good at nourishing liver and kidney, soothing the liver, and removing heat from the liver.