补肾化痰行气方联合二甲双胍治疗肥胖型多囊卵巢综合征伴胰岛素抵抗的临床研究

The Effect of Tonifying Kidney Resolving Dampness Regulating Qi Prescriptionand Metformin to Treat Polycystic Ovary Syndrome Patients with Obesity and Insulin Resistent

目的:观察补肾化痰行气方联合二甲双胍治疗肥胖型多囊卵巢综合征(PCOS)伴胰岛素抵抗(IR)的临床疗效。方法:将80例肥胖型PCOS伴CIR患者随机分为观察组和对照组,每组40例,观察组给予补肾化痰行气方联合二甲双胍治疗;对照组采用二甲双胍治疗,3个月后比较两组患者治疗前后疗效,同时对体质量指数(BMI)、血清促黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、胰岛素抵抗指数(HOMA-IR)进行比较分析。结果:观察组有效率为72.50%,对照组为52.50%,两组相比差异具有统计学意义(P<0.05);两组患者治疗前后及治疗后BMI、血清LH、LH/FSH、T、FINS、TG、HOMA-IR相比差异具有统计学意义(P<0.05);两组治疗后,血清TC均较治疗前差异具有统计学意义(P<0.05)。结论:补肾化痰行气方联合二甲双胍治疗肥胖型PCOS伴IR较单纯运用二甲双胍疗效更显著。

Objective To analyze the effect of tonifying kidney resolving dampness regulating qi prescriptionand metformin to treat polycystic ovary syndrome patients with obesity and insulin resistent. Methods 40 polycystic ovary syndrome patients with obesity and insulin resistent are randomly divided into 2 groups, the therapeutic group（40 cases） were treated with tonifying kidney resolving dampness regulating qi prescriptionand metformin, the control group（40 cases） were treated with metformin. 3 months after the effective ratio of treatment was compared, the BMI and the serum level of LH, FSH, T, FINS, TC, TG, HOMA-IR before and after treatment were detected.Results After treatment, effective ratio of therapeutic group and control group was 75.25 % and 50.25 % respectively,which had significant difference（P 0.05）, compare the BMI, serum LH、LH/FSH、T、FINS、TG、HOMA-IR of 2 groups before and after treatment, and also the indexes of 2 groups after treatment, all had significant difference（P 0.05）. Both of the serum TC of 2 groups had significant difference before and after treatment（P 0.05）. Conclusion The effect of tonifying kidney resolving dampness regulating qi prescriptionand metformin to treat polycystic ovary syndrome patients with obesity and insulin resistent is superior to metformin. Regulating the serum LH, LH/FSH,T level and modulation of obesity, lipid metabolism and insulin resistent were the mechanisms.