抗菌药物组合轮用策略对多重耐药鲍曼不动杆菌治疗效果的研究

Research of curative effect by combined antibacterial agents rotational strategy for multi-drug resistant acinetobacter baumann

目的：探讨抗菌药物组合轮用策略对多重耐药鲍曼不动杆菌的治疗效果。方法2012年6月~2014年12月收治的256例多重耐药鲍曼不动杆菌下呼吸道感染患者作为新策略组,2010年1月~2012年5月收治的210例多重耐药鲍曼不动杆菌下呼吸道感染患者作为旧策略组,观察和分析两组患者的治疗效果。结果新策略组治疗有效时间明显短于旧策略组,治疗总有效率明显高于旧策略组,差异均具有统计学意义（P〈0.05）；新策略组二线抗菌药物耐药率高于旧策略组,但差异无统计学意义（P〉0.05）。结论抗菌药物组合轮用策略能提高多重耐药鲍曼不动杆菌下呼吸道感染的治疗效果,保持抗菌药物的敏感性,值得临床治疗中推广使用。

ObjectiveTo investigate curative effect by combined antibacterial agents rotational strategy for multi-drug resistant acinetobacter baumannii.MethodsThere were 256 lower respiratory infection patients during June 2012~December 2014 with multi-drug resistant acinetobacter baumannii as new strategy group, another 210 patients during January 2010~May 2012 as old strategy group. Their curative effects were observed and analyzed.ResultsThe new strategy group had obviously shorter effective treatment time and much higher total effective rate than the old strategy group, and their differences all had statistical significance （P〈0.05）. The new strategy group also had higher drug resistance rate in 2-line antibacterial agents than the old strategy group, while their difference had no statistical significance （P〉0.05）.ConclusionImplement of combined antibacterial agents rotational strategy can improve curative effect for lower respiratory infection with multi-drug resistant acinetobacter baumannii. This method can maintain the sensitivity of antibacterial agents, and it is worth clinical promotion and application.