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ERAP 1基因多态性与银屑病研究进展

Update of ERAP1 and psoriasis
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摘要 ERAP1基因定位于5号染色体长臂(5q15),是主要编码氨基肽酶M1家族中的一个多功能酶,在血压调节、血管发生、细胞因子受体的胞外区脱落以及对抗原肽的加工中发挥作用。有研究报道ERAP1基因多态性与银屑病发病有关,本文就ERAP1结构和功能及其与银屑病的相关性进行综述。 Endoplasmic reticulum aminopeptidase1 （ ERAP1） is a gene located in the region of 5q15 with immunologic function. The gene primarily encodes a multifunctional enzyme belonging to the M1 family of aminopeptidases, which plays an important role in the regulation of blood pressure, angiogenesis, shedding of several cytokine receptors in ectodomain and processing of antigenic peptides. ERAP1gene polymorphism is associated with the pathogenesis of psoriasis. The structure and function of ERAP1 and the relation be-tween ERAP1 and psoriasis are reviewed in this paper.
作者 徐钰 王再兴 窦进法 杨森
机构地区 安徽医科大学皮肤病研究所安徽医科大学第一附属医院皮肤性病科 安徽医科大学
出处 《中国麻风皮肤病杂志》 2016年第7期439-441,共3页 China Journal of Leprosy and Skin Diseases
基金 国家自然科学基金(编号:81271747)
关键词 ERAP1基因 易感基因 银屑病 ERAP1 susceptibility gene psoriasis
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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参考文献17

  • 1Hattori A, Goto Y, Tsujimoto M. Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1 [ J ]. Biol Pharm Bull, 2012,35 (4) :601-605.
  • 2Koehan G, Krojer T, Harvey D, et al. Crystal structures of the endoplasmic reticulum aminopeptidase- 1 ( ERAP 1 ) re- veal the molecular basis for N-terminal peptide trimming[ J ]. Proe Natl Acad Sci USA,2011,108(19) :7745-7750.
  • 3Andrade MA, Petosa C, O'Donoghue SI, et al. Comparison of ARM and HEAT protein repeats[ J]. J Mol Bio1,2001,309 (1) :1-18.
  • 4Chang SC, Momburg F, Bhutani N, et al. The ER aminopep- tidase, ERAP1, trims preeursors to lengths of MHC class I peptides by a " molecular ruler" mechanism [ J ]. Proc Natl Acad Sci USA, 2005,102 (47) : 17107-17112.
  • 5Li GH, Cheung CL, Xiao SM, et al. Identification of QTL genes for BMD variation using both linkage and gene-based association approaches [ J ]. Hum Genet, 2011,130(4) : 539- 546.
  • 6Evnouchidou I, Kamal RP, Seregin SS, et al. Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic retic- ulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the en- zyme[ J]. J Immunol, 2011,186(4) : 1909-1913.
  • 7Strange A, Capon F, Spencer CC, et al. A genome-wide as- sociation study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAPI [ J ]. Nat Genet, 2010,42(11) :985-990.
  • 8Sun LD, Cheng H, Wang ZX, et al. Association analyses i- dentify six new psoriasis susceptibility loci in the Chinese population[ J]. Nat Genet,2010,42( 11 ) : 1005-1009.
  • 9Bergboer JG, Zeeuwen PL, Schalkwijk J. Genetics of psoria- sis: evidence for epistatic interaction between skin barrier ab- normalities and immune deviation [ J ]. J Invest Dermatol, 2012,132(10) :2320-2331.
  • 10Yang Q, Liu H, Qu L, et al. Investigation of 20 non-HLA (human leucocyte antigen) psoriasis susceptibility loci in Chinese patients with psoriatic arthritis and psoriasis vulgaris [ J ]. Br J Dermatol, 2013,168 (5) : 1060-1065.
中国麻风皮肤病杂志
2016年 第7期

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