盐酸氨基葡萄糖联合藤黄健骨片治疗膝骨关节炎的临床疗效评价

Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis

目的评价盐酸氨基葡萄糖联合藤黄健骨片在治疗膝骨关节炎中的临床疗效。方法选取2012年8月-2014年2月收治的180例膝骨关节炎患者,将其随机分为盐酸氨基葡萄糖组(A组)、藤黄健骨片组(B组)、盐酸氨基葡萄糖+藤黄健骨片组(C组),每组60例。治疗12周后,观察各组治疗前后的临床疗效和安全性。结果 A、B、C组患者治疗12周和停药4周后的20 m步行痛、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、关节触痛均较治疗前有明显改善(P<0.05);治疗12周与停药4周比较差异无统计学意义(P>0.05);C组治疗12周和停药4周时20 m步行痛、WOMAC、关节触痛评分均低于A、B组,差异有统计学意义(P<0.05),A、B组间比较差异无统计学意义(P>0.05)。3组患者在治疗过程中未出现血常规、尿常规异常或肝肾功能明显损害。治疗12周后,A组6例腹痛,不良反应发生率为10.0%;B组腹痛5例,腹泻2例,不良反应率为12.5%;C组腹痛4例,腹泻3例,不良反应率为12.5%。均未中断治疗。3组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论盐酸氨基葡萄糖联合藤黄健骨片治疗膝骨关节炎疗效显著,且不良反应发生率低,值得临床推广。

Objective To evaluate the therapeutic effect of glucosamine hydrochloride combined with Tenghuangjiangu tablets on knee osteoarthritis.Methods From August 2012 to February 2014,180 patients with knee osteoarthritis were randomly divided into three groups with 60 in each.Patients in group A were treated with glucosamine hydrochloride;patients in group B were treated with Tenghuangjiangu tablets;and patients in group C were treated with the combination of glucosamine hydrochloride and Tenghuangjiangu tablets.After the 12-week treatment,clinical efficacy and safety of the treatment were observed and compared with those before the treatment.Results The twenty-meter walking pain,Western Ontario and McMaster University Osteoarthritis Index（WOMAC）,and the joint tenderness in the three groups12 weeks after the treatment and 4 weeks after withdrawal improved obviously compared with those before the treatment（P〈 0.05）,and the difference between the results of 12 weeks after treatment and 4 weeks after withdrawal was not significant（P〉 0.05）.The improvement in group C was better than both group A and B with significant differences（P〈 0.05）,while the difference between group A and B was not significant（P〈 0.05）.There was no obvious abnormal routine blood and urine test result or damage of liver and lung functions during the treatment in all the three groups.Twelve weeks after treatment,six patients with abdominal ache were found in group A with an incidence of 10.0%;5 abdominal ache and 2 diarrhea were in group B with a rate of 12.5%;and 4 abdominal ache and 3 diarrhea were in group C with a rate of 12.5%.All the patients completed the treatment.No significant difference in the incidence of adverse reactions was found among the three groups（P〉 0.05）.Conclusion The therapeutic effect of combined glucosamine hydrochloride and Tenghuangjiangu tablets is obvious on knee osteoarthritis with low incidence of adverse reactions.