盐酸氨基葡萄糖联合运动疗法和中药热奄敷治疗髌股关节早期骨关节炎的临床研究

Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress

目的研究盐酸氨基葡萄糖联合运动疗法和中药热奄敷治疗髌股关节早期骨关节炎的临床疗效。方法将2013年6月-2015年4月收治的126例髌股关节早期骨关节炎患者采用随机数字表法分为A组(43例)、B组(42例)、C组(41例)。A组采用口服盐酸氨基葡萄糖+膝关节运动疗法+中药热奄敷治疗,B组采用口服盐酸氨基葡萄糖+膝关节运动疗法,C组采用膝关节运动疗法+中药热奄敷治疗。分别于治疗前及治疗后2、4、12、24周采用陈氏评分,对患者的疼痛或不适、日常活动和体征等方面进行评定。结果治疗后各时间点陈氏评分与同组治疗前比较差异均有统计学意义(P<0.05);A组治疗后各时间点陈氏评分与B、C组比较差异有统计学意义(P<0.05)。A、B组均未见服用盐酸氨基葡萄糖的明显不良反应。A组5例、C组4例患者在中药热奄敷后出现局部红疹、轻度皮肤瘙痒等接触性皮炎的症状,未作特殊处理,数小时后症状自行消失。结论盐酸氨基葡萄糖联合运动疗法和中药热奄敷治疗髌股关节早期骨关节炎能很快缓解关节疼痛,且能较长时间维持疗效。

Objective To study the clinical effect of the combination of glucosamine hydrochloride with exercise therapy and traditional Chinese medicine hot compress in the treatment of early patellofemoral osteoarthritis.Methods A total of 126 patients with early patellofemoral osteoarthritis treated between June 2013 and April 2015 were divided into group A（n=43）,B（n=42） and C（n=41） with the method of random number table.Oral administration of glucosamine hydrochloride tablets,exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 43 patients in group A.Oral administration of glucosamine hydrochloride tablets and exercise therapy of knee joints were applied for the 42 patients in group B.Exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 41 patients in group C.Chen＇s Scoring was applied before the treatment and 2,4,12 and 24 weeks after the treatment.Results The differences of Chen＇s scores at the time points after treatment and those before treatment of the same group had statistical significance（P〈 0.05）.The differences of Chen＇s scores at the time points after treatment in group A and those in group B and C had statistical significance（P〈 0.05）.There were no obvious adverse effects due to administration of glucosamine hydrochloride tablets in group A and B.Five patients in group A and 4 patients in group C suffered from the symptoms of local erythema,light cutaneous pruritus and other contact dermatitis after traditional Chinese medicine hot compress.Those symptoms disappeared automatically several hours later without any special treatment.Conclusion The treatment of early patellofemoral osteoarthritis by the combination of glucosamine hydrochloride tablets with exercise therapy and traditional Chinese medicine hot compress can rapidly relieve joint pain,and maintain efficacy for a long time.