利培酮联合有氧运动对精神分裂症患者认知功能及社会功能的影响

Effects of risperidone plus aerobatic exercise on schizophren-ics’ cognitive and social functions

目的：探讨利培酮联合有氧运动对精神分裂症患者认知功能及社会功能的影响。方法将82例精神分裂症患者按入组先后顺序分为两组，每组41例，均予以利培酮治疗，观察组在此基础上联合有氧运动治疗，观察6个月。于治疗前后采用威斯康星卡片分类测验、个人和社会功能量表及副反应量表评定认知功能、社会功能及不良反应。结果治疗2个月起，两组个人和社会功能量表评分均较治疗前显著升高（P＜0．01），观察组显著高于对照组（P＜0．01）。治疗后两组威斯康星卡片分类测验的完成分类数显著升高（P＜0．01），观察组高于对照组但差异无显著性（P＞0．05）；错误应答数、持续性应答数及非持续性错误显著降低（P＜0．01），观察组显著低于对照组（P＜0．01）。观察组失眠、体质量增加发生率显著低于对照组（P＜0．05），其他不良反应发生率两组比较无显著性（P＞0．05）。结论利培酮联合有氧运动能显著改善精神分裂症患者的认知功能及社会功能，且不增加不良反应，有利于提高患者的治疗依从性。

Objective To explore the effects of risperidone plus aerobatic exercise on schizophrenics’ cog‐nitive and social functions .Methods Eighty‐two schizophrenics were assigned to 2 groups of 41 one each according to enrolment order ,both groups treated with risperidone ,and on this basis observation group was plus aerobatic exercise for 6 months .Cognitive functions were assessed with the Wisconsin Card Sor‐ting Test （WCST ） ,social functions with the Personal and Social Performance Scale （PSP） ,and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before and after treatment .Results Since the 2nd month of treatment the PSP scores of both groups heightened more significantly compared with pretreatment （P〈0 .01） and that was significantly higher in observation than in control group （P〈0 .01） .Categories completed of the WCST of both groups heightened more significantly after treatment （P〈0 .01） , those were higher in observation than in control group , but difference wasn ’ t signi‐ficant （P〉0 .05）;error ,perseverative and non‐perseverative responses of both groups lowered more sig‐nificantly （P〈0 .01） and were significantly lower in observation than in control group （P〈0 .01） .The in‐cidences of insomnia and weight gain were significantly lower in observation than in control group （P〈0 .05） ,those of other adverse reactions had no significant group differences （P〉0 .05） .Conclusion Ris‐peridone plus aerobatic exercise could notably improve schizophrenics ’ cognitive and social functions , doesn’t increase adverse reactions ,and is beneficial to the boost of patients’ treatment compliance .