糖化血红蛋白水平对脑梗死严重程度及预后的影响

Influence of glycosylated hemoglobin on the severity and prog-nosis of cerebral infarction

目的：探讨糖化血红蛋白水平对脑梗死严重程度及预后的影响。方法将48例脑梗死患者根据血糖水平分为两组，每组24例，均予以脑血管病常规治疗，并控制血糖水平。比较两组患者的病情严重程度及临床疗效。结果治疗前高血糖组神经功能缺损程度评分显著高于对照组（P＜0．05）；治疗后两组均较治疗前显著降低（P＜0．01），高血糖组仍显著高于对照组（P＜0．01）。治疗前高血糖组脑血管病变梗死灶较大，病情较严重；治疗后高血糖组总有效率为62．5％，对照组为87．5％，高血糖组显著低于对照组（ P＜0．05）。结论高糖化血红蛋白水平脑梗死患者梗死灶较大，病情更严重，临床疗效及预后较差。

Objective To explore the influence of glycosylated hemoglobin on the severity and prognosis of cerebral infarction （CI） .Methods Forty‐eight CI patients were assigned to 2 groups of 24 ones each ac‐cording to blood sugar levels ,both groups received conventional therapy for cerebrovascular disease and controlled blood sugar levels .Intergroup severity of illness and efficacy were compared .Results Before treatment neurologic impairment score was significantly higher in high blood sugar than in control group （P〈0 .05）;after treatment neurologic impairment scores of both groups lowered more significantly （P〈0 .01） and that was significantly higher in high blood sugar than in control group （P〈0 .01） .Before treat‐ment infarction focus was larger and severity of illness greater in high blood sugar group ;after treatment total effective rate was respectively 62 .5% in high blood sugar and 87 .5% in control group ,the former significantly lower than the latter （P〈0 .05） .Conclusion Cerebral infarction patients with high glycosy‐lated hemoglobin level have larger infarction focus ,severer condition and poor efficacy and prognosis .