鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复影响的临床研究

Clinical trial of effect of mouse nerve growth factor combined gangliosides in the treatment of neurological function after brain injury in infant

目的观察不同剂量鼠神经生长因子联合神经节苷酯对婴儿脑损伤后神经功能修复的促进作用。方法 90例脑损伤患儿分为试验组和对照组,各45例。对照组在对症治疗的基础上肌内注射鼠神经生长因子30μg+静脉滴注神经节苷酯,试验组在对症治疗的基础上肌内注射鼠神经生长因子18μg+静脉滴注神经节苷酯,连续治疗14 d。比较2组患儿治疗后的临床症状、神经功能评分和智力水平。结果治疗7,14 d后,试验组患儿的神经功能性评分为(33.80±1.80),(38.20±1.90)分,与对照组的(32.20±2.40),(37.40±2.10)分,差异无统计学意义(P>0.05)。试验组神经功能改善方面的总有效率为95.56%(43/45例),与对照组的91.11%(41/45例)差异无统计学意义(P>0.05)。治疗后,试验组患儿的智力水平和脑损伤临床症状的改善与对照组差异无统计学意义(P>0.05)。不良反应主要表现为恶心呕吐和躁动,2组不良反应发生率差异无统计学意义(P>0.05)。结论低剂量的鼠神经生长因子联合神经节苷酯同样有利于婴儿脑损伤后的神经功能修复。

Objective To observe the clinical effect of different dosage of mouse nerve growth factor on nerve function recovery after brain injury in infant. Methods Ninety patients with brain injury were divided into treatment group and control group,each group 45 cases. Treatment group was treated with intravenous injection of the nerve growth factor 30 μg along with gangliosides, and control group treated with nerve growth factor 18 μg along with gangliosides. The clinical symptoms,neurological function score and intelligence level were compared between the two groups. Results After 7,14 d treatment, the neurological function scores of treatment group were（ 33. 80 ± 1. 80）,（ 38. 20 ± 1. 90）,had no significance with（ 32. 20 ± 2. 40）,（ 37. 40 ± 2. 10） in control group（ P〈0. 05）. Total efficacy in treatment group was 95. 56%（ 43 /45）,had no significance with 91. 11%（ 41 /45） in control group（ P〉0. 05）.The intelligence level and the improvement of clinical symptoms of brain injury in treatment group had no significance with control group after treatment（ P〈0. 05）. The adverse reactions mainly manifested as nausea,vomiting and restlessness,the incidence of adverse reactions had no significant difference in two groups（ P〉0. 05）. Conclusion Thelow dosage mouse nerve growth factor combined gangliosides is also beneficial to the recovery of neurological function after brain injury in infant.