期刊文献+

大肠癌动物模型的研究状况 被引量:3

Research on animal models of colorectal cancer
原文传递
导出
摘要 大肠癌(CRC)属于临床最常见的消化道肿瘤之一。大肠癌动物模型在简化复杂的发病机制和参与疾病的进展过程中至关重要。为此,本文综述了大肠癌动物模型建立方法、影响造模成功的因素等。 Colorectal cancer( CRC) is one of the most common clinical gastrointestinal cancer. Researchers,clinicians in colorectal cancer research in this area has been in continuous efforts. In this exploration of the road,the presence of colorectal cancer in animal models is unshakable. This paper reviews the methods of animal models of colorectal cancer,factors affecting successful model,and it's meaning,etc. to expand the discussion,provide a basis for a sense of colorectal further experimental research and clinical
作者 邹瑜 殷佩浩
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2016年第14期1337-1340,共4页 The Chinese Journal of Clinical Pharmacology
基金 国家自然科学基金资助项目(81473482) 上海中医药大学"研究生创新"基金资助项目(2015YCX15)
关键词 大肠癌 化学诱导 移植模型 colorectal cancer chemically-induced transplantation model
  • 相关文献

参考文献26

  • 1SIEGEL R,MA J,ZOU Z, et al. Cancer statistics[J]. CA Cancer J Clin,2014,64( 1 ) :9 -29.
  • 2SUN D,YU F,MA Y K,et al. MicroRNA -31 activates the RAS pathway and functions as an oncogenic MieroRNA in human colorec- tal eancer by repreeing RASp21 GTPase activating pmteinl ( RASA1 ) [ J]. J Biol Chem,2013,288 ( 13 ) :9508 -9518.
  • 3李慧慧,宋宝,王哲海.结直肠癌miRNA相关基因单核苷酸多态性与预后相关性研究现状[J].中华肿瘤防治杂志,2014,21(1):77-80. 被引量:13
  • 4ROSENBERG D W, GIARDINA C, TANAKA T. Mouse models for the study of colon carcinogenesis [ J ]. Carcinogenesis,2009,30 ( 2 ) : 183 - 196.
  • 5PERLE M, CERAR A. Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinoge- nesis in rats [ J ]. J Biomed Biotechnol, 2011,473964 ( 1 ) : 1 - 14.
  • 6ULGER H, ERTEKIN T. Influence of gilaburu ( Viburnum opulus) juice on 1,2 - dimethylhydrazine (DMH) - induced colon cancer [J]. Toxicol Ind Health, 2013,29(9) :824 -829.
  • 7VINOTHKUMAR R, VINOTH K R, KARTHIKKUMAR V, et al. Oral supplementation with troxerutin (trihydroxyethylrutin), modu- lates lipid pemxidation and antioxidant status in 1,2 -dimethyl- hydrazine- induced rat colon carcinogenesis [ J ]. Environ Toxicol Pharmaco1.2014.37 ( 1 ) : 174 - 184.
  • 8刘艳翠,牛莹莹,安宁.二甲基肼诱发大鼠大肠癌模型的观察[J].医学动物防制,2011,27(6):519-520. 被引量:3
  • 9何真,柯嘉,何小文,练磊,孙磊,陈泽贤,吴小剑,兰平.炎性反应促进小鼠炎性肠病癌变的研究[J].中华胃肠外科杂志,2014,17(7):706-710. 被引量:2
  • 10GRIVENNIKOV S I, GRETEN F R, KARIN M. Immunity, infla- mmation, and cancer[J]. Cell, 2010,140(6) : 883 -899.

二级参考文献105

共引文献47

同被引文献68

引证文献3

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部