西格列汀致不良反应国内外文献分析

Adverse drug reactions induced by sitagliptin:an analysis of domestic and foreign literature

目的:分析西格列汀药品不良反应的发生规律及特点,为安全合理用药提供参考。方法:检索2006年10月至2015年8月国内外学术期刊收载的西格列汀药品不良反应文献进行分析。结果:32例不良反应中,男性14例,女性18例,年龄60岁及以上患者17例(53.1%)。用药半年内发生29例(90.6%)。累及的器官或系统主要有皮肤及附件损害、肌肉骨骼系统损害及胃肠系统损害,临床表现有血管性水肿、横纹肌溶解及急性胰腺炎等。有1例患者因发生不良反应而死亡。结论:临床使用西格列汀要加强用药监测,关注药物相互作用,以减少不良反应的发生。

Objective： To analyze the general patterns and characteristics of adverse drug reactions（ ADRs） induced by sitagliptin,providing a reference for clinical medicination. Methods： ADRs of sitagliptin reported in domestic and foreign academic journals from October 2006 to August 2015 were collected from CNKI,VIP and Pubmed,and analyzed statistically. Results： Totally 32 patients of ADRs induced by sitagliptin were collected,including 14 men and 18 women. Aged patients over 60 years-old showed a higher incidence（ n = 17,53. 1%）. Sitagliptin-induced ADRs occurred within six months in 29 patients. ADRs were chiefly mainfested as skin lesion and disorders of its appendages,musculi-skeletal system disorders and gastrointestinal system disorders.The main Clinical manifestations were angioedema,rhabdomyolysis and acute pancreatitis. One patient died of adverse reactions induced by sitagliptin. Conclusion： Clinicians should tightly monitor sitagliptin using and drug interactions to reduce the incidence of sitagliptin-induced ADRs.