洛阳地区女性HPV感染及病毒亚型分布特征研究

HPV infection and genotypes analysis in Luoyang

目的：分析洛阳地区女性宫颈人乳头瘤病毒（H PV ）感染及病毒亚型分布特征。方法分析2013年6月至2015年8月于本院妇科门诊就诊的1755例初诊女性患者宫颈脱落细胞标本HPV检测结果。结果1755例标本中检出HPV阳性658例，H PV感染率为37．5％，高危型感染率为32．3％，其中单一感染占66．6％，多重感染占33．4％；在阳性样本中，高危型占86．2％，在高危型感染中，单一感染占62．3％；感染率位于前5位亚型分别为 HPV16（27．7％）、52（13．4％）、81（11．2％）、53（10．3％）、58（9．0％）。＜20、20～＜30、30～＜40、40～＜50、50～＜60、≥60岁患者H PV感染率分别为40．0％、42．7％、34．3％、34．7％、43．7％、38．0％，高危型感染率分别为40．0％、34．9％、29．4％、30．3％、38．0％、34．2％。结论本地区女性宫颈 H PV感染率较高，以单一感染为主。在HPV感染者中，高危型感染所占比例较高，也以单一感染为主。 HPV感染优势型别以 HPV16、52为主。H PV感染与女性年龄因素相关，50～＜60岁患者感染率最高。

Objective To investigate the infection and genotype character of human papilloma virus （HPV ） in females of Luoy‐ang .Methods Results of HPV genotyping of 1 755 female outpatients in Gynecology Clinic of this hospital ,from June 2013 to Au‐gust 2015 ,were analyzed .Results Among 1 755 cases ,658 cases were positive with HPV ,with positive rate of 37 .5% ,high risk‐HPV infection rate of 32 .3% .Single genotype infection rate was 66 .6% ,and multiple genotypes infection rate was 33 .4% .In the positive cases ,68 .2% was high risk‐HPV infection ,and the single infection rate was 62 .3% .The top five common HPV subtypes were HPV16（27 .7% ） ,52（13 .4% ） ,81（11 .2% ） ,53（10 .3% ） and 58（9 .0% ） .The HPV positive rates in 〈20 ,20 - 〈30 ,30 - 〈40 ,40- 〈50 ,50- 〈60 and ≥60 years group were 40 .0% ,42 .7% ,34 .3% ,34 .7% ,43 .7% and 38 .0% ,and high risk‐HPV posi‐tive rates were 40 .0% ,34 .9% ,29 .4% ,30 .3% ,38 .0% and 34 .2% .Conclusion Females in this region could be with high HPV infection rate ,with dominant single genotype infection .In HPV positive cases ,high risk‐HPV infection might be more common ,and single high risk‐HPV infection might account for a large proportion .The most common HPV genotypes could be HPV16 and HPV52 .HPV infection might be associated with age ,and females of 50 - 〈60 years old could be with the highest HPV infection rate .