肺癌伴发感染患者降钙素原和炎性因子的检测及临床意义

PCT and Proinflammatory Cytokine Assay and Its Importance for Lung Cancer Patients Combined with Infection Disease

目的:检测肺癌伴发感染患者降钙素原(PCT)和炎性因子含量并探讨其临床意义。方法:以临床确诊肺癌伴发全身感染患者为试验组,以单纯肺癌患者为对照组,采血测定外周血白细胞计数(WBC)、PCT、C-反应蛋白(CRP)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)等含量。结果:感染患者WBC与对照组相比显著升高[(8.31±1.42)×109/L vs.(5.85±1.08)×109/L,,差异有统计学意义(P<0.01)];PCT显著升高[(1.74±0.22)ng/ml vs.(0.65±0.10)],差异有统计学意义(P<0.01);CRP各组差异无统计学意义(P>0.05),但远高于正常值范围;IL-1含量显著升高[(15.38±2.56)pg/ml vs.(6.43±2.07)pg/ml],差异有统计学意义(P<0.01);IL-6含量显著升高[(164.27±21.79)pg/ml vs.(95.30±19.17)pg/ml],差异有统计学意义(P<0.01);TNF-α含量显著也升高[(1.22±0.15)ng/ml vs.(0.89±0.15)ng/ml],差异有统计学意义(P<0.01)。使用抗感染药物控制感染后,感染患者上述指标均降至对照水平。结论:PCT是判定肺癌患者伴发感染的良好指标。

Objective To detect the levels of serum precalcitonin（PCT）and proinflammatory cytokines in lung cancer patients with systemic bateria infection and explore its clinical implications.Method Lung cancer patients with systemic bacteria infection were classified into experimental group,and lung cancer patients without bacteria infection were classified into control group.Venous blood was taken and managed for assay of white blood cell account,serum levels of PCT,C -response protein （CRP）,IL -1,IL -6 and TNF -α.Results White blood cell account in lung cancer patients with systemic bacteria infection was notably higher than that in control group [（8.31 ±1.42）×109 /L vs.（5.85 ±1.08）×109 /L,P 〈0.01].Serum PCT level was significantly higher in infected patients than that in control group [（1.74 ±0.22）ng/ml vs.（0.65 ±0.10）],the difference was statistically significant （P 〈0.01）.No remarkable change was found between experimental group and control group for serum CRP level （P 〉0.05）. However,the CRP levels in both groups were much higher than that in normal standard.Serum IL -1 level in experimental group was significantly higher than that in control [（15.38 ±2.56）pg/ml vs.（6.43 ±2.07）pg/ml,P 〈0.01].Serum IL -6 level was remarkably higher than that in control[（164.27 ±21.79）pg/ml vs.（95.30 ±19.17）pg/ml,P 〈0.01].Serum TNF -αlevel in experimental group was also notably higher than that in control group[（1.22 ±0.15）ng/ml vs.（0.89 ±0.15）ng/ml,P 〈0.01] .All of the elevated indexes in this experiment dropped to control levels after the bacteria infection was controlled by antibiotic drugs.Conclusion PCT is a reliable index to determine systemic bacteria infection for lung cancer patients.