慢性阻塞性肺疾病应用低分子肝素钠的治疗效果分析

Analysis of the treatment effect of low molecular weight heparin in treatment of chronic obstructive pulmonary disease

目的:探讨低分子肝素钠辅助治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法:66例COPD患者进行随机分组:对照组(33例)接受COPD临床常规治疗,观察组(33例)加用低分子肝素钠进行治疗,对比两组患者治疗前后肺功能、动脉血气以及血液学指标等变化情况。结果:观察组与对照组的治疗总有效率分别为96.97%、84.85%,观察组显著高于对照组,差异有统计学意义(P<0.05);治疗后两组的肺功能指标(FEV1、FEV1/EVC)、动脉血气指标(Pa O2、Pa CO2)及血液学指标(WBC、D-D及HCT)均较治疗前显著改善,且观察组的改善幅度显著优于对照组,差异有统计学意义(P<0.05);观察组的住院时间较对照组显著缩短,差异有统计学意义(P<0.05)。结论:低分子肝素钠辅助治疗COPD能够提高临床疗效、改善患者的肺功能、预防肺栓塞、促进病情康复,值得在临床中推广应用。

Objective To evaluate the clinical efficacy of low molecular weight heparin adjuvant treatment of chronic obstructive pulmonary disease （COPD）.Method 66 cases of COPD patients were randomly divided into two groups：The control group （33 ca-ses）received conventional clinical treatment of COPD,the observation group （33 cases）added low molecular weight heparin for treatment,the changes of two groups of pulmonary function,arterial blood gas and hematology indicators before and after treatment were compared.Results The total effective rate of observation group and control group was 96.97%,84.85%,respectively,that of observation group was significantly higher than that of control group,the differece was statistically significant （P 〈0.05）;After treatment,the pulmonary function （FEV1 ,FEV1 /EVC）,arterial blood gas analysis （PaO2 ,PaCO2 ）and hematological indices （WBC,D -D and HCT）of the two groups were significantly improved than before treatment,and the observation group were signifi-cantly better than the control group,the differece was statistically significant （P 〈0.05）;The hospitalization time of observation group was significantly reduced than the control group,the differece was statistically significant （P 〈0.05）.Conclusion The low molecular weight heparin adjuvant therapy for COPD can improve the clinical efficacy,improve the patient′s lung function,prevent pulmonary embolism and promote disease recovery,it is worth promoting in clinical applications.