结合年龄探讨抗苗勒氏管激素筛查在孕前保健中的应用

Application of age combined with anti-müllerian hormone screening in preconception care

目的 结合年龄探讨抗苗勒氏管激素（anti-müllerian hormone,AMH）筛查在孕前保健中的应用价值。方法 将2015年4月至2015年9月于成都市妇女儿童中心医院妇女保健中心进行孕前保健检查的1 426例25~40岁妇女分为25~30岁、31~35岁、36~40岁3组,采用血清AMH筛查,分析检验结果。结果 1 426例受检者AMH水平随年龄增长逐渐降低,3组比较差异有统计学意义（P〈0.05）;36~40岁AMH〈1.1 ng/m L的比例显著高于其他两组,差异有统计学意义（P〈0.05）;1 426例受检者中有不孕症者184例,占总筛查人数的12.9%;其AMH〈1.1ng/m L的比例明显高于其他孕前检查者,差异有统计学意义（P〈0.05）。结论 在孕前保健中,35岁以上的妇女通过筛查血清AMH水平,有助于提高隐匿性卵巢储备功能降低的检出率,以促进妇女进行更合理的生育规划及指导不孕症治疗方案的决策。

Objective To study the application value of age combined with anti -mttllerian hormone （AMH） screening in preconception care. Methods 1 426 women aged from 25 to 40 who took preconception examination in Women and children＇ s central hospital of Chengdu from April 2015 to September 2015 were selected, divided them into 25 -30 years group, 31 - 35 years group, 36 ~ 40 years group,did AMH screening and analyzed test results. Results In 1 426 cases,the levels of AMH levels reduced gradually with age, the differences of three groups were statistically significant （P 〈 0. 05 ） ;the ratio of whose AMH 〈 1.1 ng/mL in the group of 36 ~ 40 years old was significantly higher than the other two groups significantly （P 〈 0. 05 ） ;there were 184 cases of infertility in 1 426 women, the ratio of whose AMH 〈 1. 1ng/mL in the women with infertility was significantly higher than other examiner, there was a statistically significant difference （ P 〈 0.05 ）. Conclusion Women over the age of 35 before pregnancy, there is a need for screening for serum anti -mtillerian hormone to help increase detection rate of occult ovarian reserve function （decreased ovarian reserve, DOR）, and promote women＇ s fertility planning and guide decision -making on？ fertility treatment？ programmes.