中药药熨联合微波理疗治疗慢性盆腔炎临床研究

TCM Hot Medicinal Compress Therapy Combined with Microwave Therapy in Treatment of Chronic Pelvic Inflammatory Disease

目的:探讨中药药熨联合微波理疗治疗慢性盆腔炎的临床疗效及对血液流变学和炎症因子的影响。方法:将120例患者按随机数字法分为对照组和观察组,每组60例。对照组采用头孢噻肟钠注射液和替硝唑注射液治疗,静脉滴注,每日1次;观察组在对照组的基础上加用中药药熨联合微波理疗治疗。两组患者疗程为4周。比较治疗后两者患者临床疗效,治疗前后全血黏度、血浆黏度、纤维蛋白原、血小板聚集率等血液流变学指标,治疗前后白细胞介素-2(interleukin-2,IL-2)、白细胞介素^(-1)0(interleukin^(-1)0,IL^(-1)0)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平以及治疗前后中医证候评分。结果:观察组有效率为95.0%,对照组有效率为83.3%,两组比较,差异有统计学意义(χ~2=4.227,P<0.05);治疗后观察组中医证候评分低于对照组,差异有统计学意义(P<0.01);治疗后观察组血液流变学指标(全血黏度、血浆黏度、纤维蛋白原、血小板聚集率)均低于对照组,差异有统计学意义(P<0.01);治疗后观察组TNF-α水平低于对照组,IL-2和IL^(-1)0水平高于对照组,差异有统计学意义(P<0.01)。结论:在西医常规抗生素治疗的基础上,加用中药药熨联合微波理疗治疗慢性盆腔炎能改善患者症状、促进血液循环、减轻炎症反应,提高临床疗效。

Objective： To investigate the clinical efficacy of TCM hot medicinal compress therapy combined with microwave therapy in treatment of chronic pelvic inflammatory disease and its effect on blood rheology and inflammatory factors. Methods： 120 patients were randomly divided into control group and observation group,with 60 cases in each group. The control group was treated with cefotaxime sodium injection and tinidazole injection therapy and the intravenous infusion was conducted once a day. Based on the treatment of the control group the observation group also received TCM hot medicinal compress theory and microwave therapy. Both groups of patients received treatment for 4 weeks. The therapeutic effect of the two patients was compared,which includes the whole blood viscosity,plasma viscosity,fibrinogen,platelet aggregation rate,blood rheology,interleukin-2（ IL-2）,interleukin^（-1）0（ IL^（-1）0）and tumor necrosis factor-α（ TNF-α） levels as well as traditional Chinese medicine syndrome scores before and after treatment.Results： The effective rate of the observation group was 95. 0% and that of the control group was 83. 3%. The difference of the two groups was statistically significant（ χ~2= 4. 227,P 〈0. 05）. TCM syndrome score of the observation group after treatment was significantly lower than that of the control group（ P 〈0. 01）. After treatment,the hemorheology indexes（ i. e. the whole blood viscosity,plasma viscosity,fibrinogen,platelet aggregation） of the observation group were significantly lower than those of the control group（ P 〈0. 01）. After treatment,the level of TNF-α of the observation group was significantly lower than that the control group while the IL-2 and IL^（-1）0 levels were significantly higher than those of the control group（ P 〈0. 01）. Conclusion： On the basis of western conventional antibiotic treatment,TCM hot medicinal compress therapy combined with microwave therapy in treatment of chronic pelvic inflammatory disease would achieve satisfied clinical efficacy,which can improve symptoms,promote blood circulation,reduce inflammation and improve clinical outcomes.