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血管内皮生长因子与CD105对上皮性卵巢癌的表达及其与血管新生的关系分析

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摘要 目的:分析血管内皮生长因子(Vascular endothelial growth factor,简称VEGF)与CD105在上皮性卵巢癌中的表达及其与血管新生的关系。方法:采用免疫组化法对90例手术切除卵巢癌患者的卵巢染色及血管标记和30例正常人体卵巢组织作对照,测定VEGF蛋白及CD105-MVD的含量。结果:VEGF及CD105在卵巢癌中的表达率明显高于正常卵巢组织(P<0.05),VEGF的阳性表达及CD105-MVD与上皮性卵巢癌的临床分期、病理组织分级、是否伴淋巴结转移有相关性(P<0.01),与年龄无相关性(P>0.05);上皮性卵巢癌组织中VEGF的阳性表达与CD105-MVD含量呈显著正相关(P<0.01)。结论:上皮性卵巢癌中VEGF和CD105的表达与卵巢癌生物学行为密切相关,这为上皮性卵巢癌的预防、诊断、治疗及预后提供良好的实验依据。
作者 李夏芳
出处 《抗感染药学》 2016年第3期605-608,共4页 Anti-infection Pharmacy
基金 赣州市指导性科技计划项目(编号:GZ2015ZSF174)
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参考文献9

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