Kartogenin与软骨修复的研究进展

Research progress in kartogenin and cartilage repair

骨关节炎是一种由多因素引起的退行性病变,以关节软骨退化、关节边缘和软骨下骨反应性增生为特征,而干细胞用于软骨再生有良好的发展前景。目前,一种新的小分子化合物kartogenin(KGN)被发现,它拥有极强的促软骨分化能力,能有效地促进间充质干细胞向软骨细胞分化。当KGN可明显抑制白介素1β(interleukin 1β,IL-1β)引起的细胞外基质和蛋白聚糖的减少,同时KGN对于促进软骨细胞分泌物lubricin的分泌与转化生长因子β1(transforming growth factorβ1,TGF-β1)、骨形态发生蛋白7(bone morphogenetic protein 7,BMP-7)具有协同作用,此外,KGN还促进腱-骨连接处形成软骨样组织,并且与壳聚糖结合的KGN较未结合的KGN成软骨能力更强。本文就KGN对于软骨修复的研究进展作一综述。

As a degenerative disease caused by multiple factors, osteoarthritis is characterized by articular cartilage degeneration and reactive hyperplasia of joint edge and the subchondral bone. Recently, kartogenin （KGN） was identified to promote chondrocyte differentiation. KGN can block interleukin 1β（IL-1β）-eaused loss of extracellular matrix and proteoglyean. Transforming growth factor β1 （TGF-β1）, bone morphogenetic protein 7 （BMP-7）, and KGN together can synergistically promote the expression of lubricin in chondrocytes. KGN can also induce cartilage-like tissue formation in tendon-bone junction. In addition, chitosan （CHI）-KGN nanopartieles and CHI-KGN microspheres can more effectively induce chondrogenic differentiation than uneonjugated KGN. Here in this paper we summarized the roles of KGN in regulating the cartilage regeneration.