宫颈癌患者血清25-羟维生素D水平及相关性研究

The Correlation Study of Serum 25-hydroxyvitamin D Levels in Patients with Cervical Cancer

目的探讨血清25-羟-维生素D水平与宫颈癌发生发展及相关临床因素的关系。方法收集2013年1月至2015年1月因宫颈疾病在我院治疗且具备活检病理结果的患者286例,其中慢性宫颈炎57例,低度鳞状细胞内病变76例,高度鳞状细胞内病变85例,宫颈癌68例。采集血清标本用ELISA法检测25-羟维生素D水平,结合临床资料进行分析。结果宫颈癌组患者血清25-OH)D水平显著低于其他宫颈疾病患者,差异有统计学意义(P均<0.05);血清25-(OH)D水平与宫颈癌患者临床分期、分化程度密切相关,而与年龄、月经情况、淋巴结有无转移无关,血清25-(OH)D水平与临床分期相关系数r=-0.585,P<0.05具有相关性,与分化程度相关系数r=-0.643,P<0.01,具有相关性。结论血清25-羟维生素D水平与宫颈癌的发生发展相关,与临床分期、分化程度具有相关性。

Objective To investigate the serum 25-hydroxyvitamin D （25 （OH） D） levels and and its association with clinical factors in cervical cancer. Methods We enrolled 286 cases of patients with cervical disease from January 2013 to January 2015 in our hospital. Serum 25（OH） D levels was detected by ELISA method. Related clinical data were analyzed. Results Serum 25 （OH） D was significantly lower than that of other types of cervical diseases, the difference was statistically significant （P 〈 0.05）. Serum 25 （OH） D levels were closely associated with cervical cancer clinical stage and tumor differentiation. There was no correlation with age, menstrual conditions, or with and without lymph node metastasis. Serum 25 （OH） D level and clinical staging was correlated with correlation coefficient r = 0.585, P 〈 0.05. Correlation Coefficient for differentiation was r = 0.643, P 〈 0.01. Conclusions The 25- hydroxy serum vitamin D levels were associated with the development of cervical cancer, It was correlated with clinical staging and tumor differentiation.