高乌甲素凝胶贴膏的流变学研究

Rheological Research of Lappaconitine Cataplasm

目的利用流变学对高乌甲素凝胶贴膏配方进行研究。方法利用SMS物性测试仪测定胶强度,初步筛选高乌甲素凝胶贴膏的填充剂,然后利用旋转流变仪考察填充剂的用量和增黏剂对流变学的影响。结果微粉硅胶增加基质胶强度最好,选作填充剂。流变学测定显示微粉硅胶可增加凝胶贴膏的弹性模量(elastic modulus,G′)和黏性模量(viscous modulus,G″),对前者增加效果更好,最佳含量为2.5%;不同增黏剂均显著增加G″,而PVA对G′影响小,故选作增黏剂。采用中国药典2015年版第四部的黏附性检查法证实优化的高乌甲素凝胶贴膏黏附性能良好。结论流变学参数是筛选凝胶贴膏处方的一种有用工具。

OBJECTIVE To research on the formulations of lappaconitine cataplasm by means of rheology METHODS The gel strength was measured by SMS Texture Analyser and the fillers of lappaconitine cataplasm were preliminary screen out. The rheology was measured by Malvern Rotational Rheometer and then the dosage of fillers and tackifiers were investigated and determined. RESULTS Aerosol could increase gel strength most remarkably and was designated as filler. Rheological measurement showed the aerosol could increase elastic modulus（G′） and viscous modulus（G″） simultaneously, but the former was more remarkable and the optimal content was 2.5%; All kinds of tackifiers could increase G″ remarkably. PVA have the least influence on G′ and was screened out as tackifier. The adhesiveness examination according to the 2015 edition of Chinese Pharmacopoeia（Part Ⅳ） verified the optimized lappaconitine cataplasm has good adhesive property. CONCLUSION Rheological parameters are useful tools for screening out the formulations of cataplasm.