益气活血法联合丁苯酞治疗急性脑梗死64例

Sixty-Four Cases with Acute Cerebral Infarction Treated by the Method of Benefiting Qi and Activating Blood Flow Combined with Butylphthalide

目的:观察益气活血法联合丁苯酞治疗急性脑梗死的临床疗效,并观察其对血液流变学和炎症因子的影响。方法:将125例患者随机分为治疗组64例和对照组61例。对照组采用丁苯酞治疗,治疗组在对照组的基础上联合益气活血法。两组患者的临床疗效、治疗前后血液流变学、炎症因子水平、神经功能缺损评分及治疗期间不良反应发生情况等。结果:治疗组有效率为90.63%,对照组有效率为77.05%,两组有效率比较,差异具有统计学意义(P<0.05);两组患者治疗后血浆黏度、红细胞压积、全血低切黏度、全血高切黏度显著低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05);两组患者治疗后血清白介素-6(interleukin-6)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)水平低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05);两组患者治疗后神经功能缺损评分低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05);两组均未发生明显不良反应。结论:益气活血法联合丁苯酞治疗急性脑梗死患者临床疗效显著,可能与降低炎症因子和改善血液流变学相关,且安全性良好。

Objective ：To observe the clinical effects of the method of benefiting qi and activating blood flow combined with Bu- tylphthalide on acute cerebral infarction （ACI） and its influence on the hemorheology and inflammatory factor. Methods：Totally 125 patients were randomly divided into treatment group （64 cases） and control group （61 cases）. Control group were given Butylphthalide for the treatment while treatment group were added with the method of benefiting qi and ar.tivatmg blood flow. The clinical effects in both groups, and bemorheology, levels of inflammatory factors before and after the treatment, scores of neurologic impairment and adverse reactions during the treatment were observed. Results：The effective rate was 90.63% in treatment group and 77.05% in control group; the difference had statistical significance （P 〈 0.05 ）. After the treatment, the plasma viscosity, packed cell volum,low-cut viscosity of whole blood and high-cut viscosity of whole blood got marked decline, and the decline in treatment group was greater than that in control group ;the difference had statistical significance （P 〈 0.05 ）. The levels of interleukin-6 and TNF-cdn both groups were lower than these before treatment, and the level in n treatment group was lower than that in control group,with statistical significance （P 〈0.05 ）. The scores of neurologic impairment after the treatment in both groups were lower than these before treatment,and the score in treatment group was lower than that in control group, with statistical sig- nificance （ P 〈 0. 05 ）. There were no obvious adverse reacuons in both groups. Conclusion ： The method of benefiting qi and acti- vating blood flow combined with Butylphthalide has remarkable and safe therapeutic effects on ACI. which mav be associated with the decline of inflammatory factor and the improvement of hemorheology.