舒郁清消汤治疗2型糖尿病合并抑郁症临床研究

Clinical Research on the Shuyu Qingxiao Decoction for Treating Type 2 Diabetes Complicated with Depression

目的:观察舒郁清消汤治疗2型糖尿病合并抑郁症的临床疗效。方法:将80例2型糖尿病合并抑郁症患者随机分为对照组、氟西汀组、中药组及综合组,每组各20例。对照组给予糖尿病的基础治疗,氟西汀组服用氟西汀胶囊,中药组口服舒郁清消汤,综合组同时服用氟西汀胶囊及舒郁清消汤。观察各组患者治疗前后HAMD抑郁量表积分及生化指标变化情况。结果:氟西汀组、中药组、综合组治疗后HAMD积分较治疗前均有显著下降,与对照组治疗后比较,差异具有统计学意义(P<0.01)。氟西汀组、中药组、综合组治疗后空腹血糖(Fasting blood glucose,FPG),餐后血糖(Postprandial blood glucose,PPG),糖化血红蛋白(glycosylated hemoglobin,Hb AIC)、空腹C肽水平较治疗前均有下降,与对照组治疗后比较,差异具有统计学意义(P<0.01)。结论:舒郁清消汤治疗2型糖尿病合并抑郁症临床疗效确切,不良反应较少。

Objective：To observe the clinical effects of Shuyu Qingxiao Decoction on type 2 diabetes complicated with depression. Methods：Totally 80 patients with type 2 diabetes complicated with depression were randomly divided into control group, fltuxetine group,Chinese medicine group and comprehensive group, with 20 cases in each group. Control group were given basic treatment for diabetes;fluxetine group were given f/uxetine capsules;Chinese medicine group were orally given Shuyu Qingxiao Decoction; comprehensive group were given fluxetine capsules combined with Shuyu Qingxiao Decoction. The scores of HAMD depression scales and the changes of biochemical criteria before and after the treatment in each group were observed. Results：The scores of HAMD in fluxetine group, Chinese medicine group and comprehensive group got marked decline;compared with control group, the difference had statistical significance （P 〈 0.01 ）. The levels of FPG. PPG, HbAIC and level of c peptide with empty stomach in fluxetine group, Chinese medicine group and comprehensive group got remarkable decrease after the treatment ; compared with control group,the difference had statistical significance（ P 〈 0.01 ）. Conclusion： Shuyu Qingxiao Decoction has definite therapeutic effects on type 2 diabetes complicated with depression and it has little adverse reaction.