不同酒种对血清Hcy及颈动脉粥样硬化的影响

The effect of different types of alcohol on serum Hcy and carotid atherosclerosis

目的探讨饮用白酒及啤酒对血清同型半胱氨酸（Hcy）及颈动脉粥样硬化的影响。方法 选择2013年10月~2016年1月陕西省中医医院诊治的颈动脉粥样硬化男性患者217例,其中有大量饮酒史141例,无饮酒史76例,依据饮酒种类分为3组,白酒组（68例）、啤酒组（73例）、不饮酒组（76例）。分别测定血清同型半胱氨酸（Hcy）和颈动脉斑块检出率。结果 白酒组和啤酒组血清Hcy及斑块检出率较不饮酒组均明显升高,差异有统计学意义（P〈0.05）。啤酒组较白酒组血清Hcy及斑块检出率明显降低,差异有统计学意义（P〈0.05）。结论 大量饮酒不论白酒或啤酒均导致血清Hcy升高,动脉粥样硬化病变加重,饮用啤酒较白酒对血清Hcy、颈动脉粥样硬化影响小。

Objective To investigate the effects of drinking liquor and beer on serum Hcy and carotid atherosclerosis.Methods From October 2013 to January 2016, in Shaanxi Province Hospital of Traditional Chinese Medicine, 217 male patients with carotid atherosclerosis were selected, including 141 cases with history of heavy drinking, 76 cases with no history of alcohol consumption, according to the alcohol type, they were divided into three groups, spirit group（68 cases）, beer group（73 cases）, non-drinking group（76 cases）. The serum homocysteine（Hcy） and detection rate of plaque were measured respectively. Results The detection of serum homocysteine and detection rate of plaque in spirit and beer groups were significantly increased than non-drinking group, the differences were statistically significant（P 0.05）. Beer group compared with group liquor, the Hcy and detection rate of plaque were significantly lower, the differences were statistically significant（P 0.05）. Conclusion Drinking a lot of alcohol, whether spirit or beer, lead to the elevated levels of Hcy and atherosclerosis lesions. Compareing with spirit, the effects of alcohol on serum Hcy and carotid atherosclerosis was small in drinking beer.