比较尿毒症期糖尿病肾病与高血压肾病肾脏弹性变化

Elasticity changes between diabetic nephropathy and hypertensive renal disease in uremia stage

目的:比较糖尿病肾病与高血压肾病在尿毒症期肾脏弹性变化的特点,并测量肾脏皮质厚度,分析其与皮质弹性指数(elastic index,EI)的相关性。方法:尿毒症期患者38例,其中糖尿病肾病组20例、高血压肾病组18例,采用独立样本t检验分别比较两组肾脏皮质、髓质及肾窦EI值及皮质厚度的差异,并分析皮质厚度与皮质EI值之间的相关性。结果:尿毒症期,糖尿病肾病组皮质区的EI值高于高血压肾病组(t=-2.37,P<0.05);在髓质区,糖尿病肾病组EI值低于高血压肾病组(t=2.43,P<0.05);两组肾窦的EI值差异无统计学意义(t=0.55,P>0.05)。糖尿病肾病组与高血压肾病组皮质厚度的差异无统计学意义(t=-1.01,P>0.05)。肾脏皮质厚度与皮质EI值存在正相关(r=0.35,P<0.05)。结论:在尿毒症期,糖尿病肾病与高血压肾病患者的肾脏EI值有不同变化,皮质厚度与皮质EI值之间呈正相关。

Objective：To compare the elasticity changes between diabetic nephropathy and hypertensive renal disease in the uremia stage,and measure the thickness of the renal cortex to analyze its relationship with elastic index （EI） of the cortex. Methods：A total of 38 uremia patients were divided into two groups： diabetic nephropathy group （n=20） and hypertensive renal disease group （n=18）. Independent-samplest test was used to compare EI values in the cortex, medulla and sinu between the two groups. The correlation between the thickness of the cortex and EI value of the cortex was investigated.Results：In the cortex, EI value in the diabetic nephropathy group was higher than that in the hypertensive renal disease group（t=-2.37,P〈0.05）; while in the medulla, EI value in the diabetic nephropathy group was lower than that in the hypertensive renal disease group （t=2.43,P〈0.05）. There was no significant difference in EI value in the sinu between the two groups （t=0.55,P〉0.05）. There was no significant difference in the thickness of the cortex between the two groups （t=-1.01,P〉0.05） . The thickness of the cortex was correlated with EI value （r=0.35,P〈0.05）.Conclusion：In the uremia stage, there are different changes in renal elasticity between diabetic nephropathy and hypertensive renal disease. Cortical EI value is positively correlated with its thickness.