针刺大钟、太溪组穴脑激活区功能MRI研究

A study of acupuncture Dazhong and Taixi acupointsbased on fMRI

目的应用血氧水平依赖功能MRI技术(blood oxygen leveldependent functional magnetic resonance imaging,Bold-f MRI)观察同时针刺右侧足少阴肾经大钟、太溪组穴引起的脑部激活信号改变情况,探讨针刺大钟、太溪组穴脑激活区与单独针刺上述两个穴位产生的脑激活区相似性和差异性,以及针刺穴位引起的脑特异性反应。材料与方法使用3.0 T双源双梯度MR扫描仪采集14名健康志愿者针刺右侧大钟、太溪组穴时Bold信号数据,使用spm12(statistical parametric mapping)软件包对采集到的图像数据进行处理和统计学分析。结果针刺大钟、太溪组穴引起的正激活脑区包括:左侧额叶、中央前回(Ba44)、额下回,右侧岛叶(Ba13)、额叶、小脑前叶、丘脑、小脑后叶、顶叶(Ba22)、中央后回(Ba4);负激活脑区包括:左侧中脑,右侧边缘叶,海马回(Ba17)。结论针刺大钟、太溪穴组穴引起的激活脑区与已往单独针刺上述两个穴位比较不是简单的叠加效应,而是存在特异性激活脑区;针刺大钟、太溪组穴引起的脑激活区可能与其产生的临床疗效相关;针刺大钟、太溪组穴可引起大脑相对特异性反应。

Objective： Using functional magnetic resonance imaging to observe the brain blood oxygen level dependent signal change by acupuncturing the right side of kidney channel of foot shaoyin Dazhong and Taixi acupoints, to explore the relationship between efficacy and activate brain areas. To observe the brain blood oxygen level dependent signal change by acupuncturing the right side of kidney channel of foot shaoyin Dazhong and Taixi acupoints based on blood oxygen level dependent functional magnetic resonance imaging, and to explore the relationship between efficacy and activate brain areas. Materials and Methods： Using 3.0 T dual-source double gradient magnetic resonance to collect the Bold signal data of 14 healthy volunteers who were acupunctured the right side of kidney channel of foot shaoyin Dazhong and Taixi acupoints, then using SPM12（statistical parametric mapping） to process data and statistical analysis. Results： The active cerebral areas by acupuncturing Dazhong and Taixi acupoints include： The left frontal lobe, left medial frontal gyrus（Ba44）, left inferior frontal gyrus and right insula（Ba13）, right frontal, right cerebellum anterior lobe, right thalamus, right cerebellar lobe, right parietal lobe（Ba22）, right posteriorcentral gyrus（Ba4）, deactivate brain regions include： The left side of the midbrain, the right side Limbic lobe and hippocampus（Ba17）. Conclusion： Acupuncture Dazhong and Taixi acupoints can cause the relative specificity reaction helpful to early diagnosis and condition evaluation. specificity reaction of brain central nervous. Its curative effect is closely associated with the limbic system especially the thalamic activation.