VEGF和SLeX表达与甲状腺乳头状癌浸润转移的关系

Expressions of VEGF and SLe X in Papillary Thyroid Carcinoma and Their Relationships with Invasion and Metastasis

目的:探讨VEGF和SLe X在甲状腺乳头状癌中的表达及其与癌组织浸润转移的关系。方法:应用免疫组化染色Eli VisionTM plus两步法检测164例甲状腺乳头状癌组织和30例癌旁甲状腺组织中VEGF和SLe X的表达状况。结果:癌组织中VEGF和SLe X总体阳性表达率分别为59.8%(98/164)和70.7%(116/164),癌旁甲状腺组织中VEGF和SLe X总体阳性表达率分别为13.3%(4/30)和6.7%(2/30),两者在癌组织总体阳性表达率显著高于癌旁组织(P<0.05);有浸润患者VEGF和SLe X总体阳性表达率分别为69.7%(69/99)和84.8%(84/99),无浸润患者分别为44.6%(29/65)和49.2%(32/65),两者在有浸润患者中的总体阳性表达率均显著高于无浸润患者(P<0.05);有淋巴结转移患者VEGF和SLe X总体阳性表达率分别为69.9%(65/93)和89.2%(83/93),无淋巴结转移患者均为46.5%(33/71),两者在有淋巴结转移患者中的总体阳性表达率均显著高于无淋巴结转移患者(P<0.05)。癌组织VEGF与SLe X表达呈正相关(r=0.59)。结论:VEGF和SLe X在甲状腺乳头状癌组织中多数呈强阳性表达,两者与癌组织浸润转移密切相关。

Objective：To investigate the expressions of VEGF and SLe X in papillary thyroid carcinoma and their relationships with the potential of invasion and metastasis.Method：The expressions of VEGF and SLe X in 164 cases of papillary thyroid carcinoma and 30 cases of para-tumorous tissue were studied by Eli VisionTM plus twostep immunohistochemical method.Result：The positive rates of VEGF and SLe X in papillary thyroid carcinoma were 59.8%（98/164）and 70.7%（116/164）,both were significantly higher than those in para-tumorous tissue（P〈0.05）.The positive rates of VEGF and SLe X in the patients with tumor invasion were 69.7%（69/99）and 84.8%（84/99）,both were significantly higher than those in without tumor invasion（P〈0.05）.The positive rates of VEGF and SLe X in the patients with lymphatic metastasis were 69.9%（65/93）and 89.2%（83/93）,both were significantly higher than those in without lymphatic metastasis（P〈0.05）.There was a positive correlation between VEGF and SLe X expression（r=0.59）.Conclusion：High level expressions of VEGF and SLe X in papillary thyroid carcinoma are closely correlated with the invasive and metastasic potential.