重用黄芪自拟方联合奥拉西坦胶囊对脑卒中后痴呆患者高级脑功能的影响

Effect of Self-made Fang with High Dose of Astragali Combined with Oxiracetam Capsules on Higher Brain Functions of Patients with Dementia after Stroke

目的:观察重用黄芪自拟方联合奥拉西坦胶囊对脑卒中后痴呆患者高级脑功能的影响。方法:选取92例脑卒中后痴呆患者作为研究对象,按随机数字表法分为研究组和对照组各46例。对照组予以奥拉西坦胶囊治疗,研究组在对照组用药基础上加用重用黄芪自拟方治疗。比较2组临床疗效,评估2组治疗前后的痴呆程度以及认知功能和记忆功能,检测2组治疗前后超氧化物歧化酶(SOD)和血浆脂质过氧化物(LPO)含量。结果:总有效率研究组为89.13%,高于对照组的69.57%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组长谷川量表(HDS)、简易智能表(MMSE)、韦氏记忆测验(WMS)评分比较,差异均无统计学意义(P>0.05)。治疗后,2组HDS、MMSE、WMS评分均较治疗前升高(P<0.05),研究组的各项评分均高于对照组(P<0.05)。治疗前,2组SOD、LPO含量比较,差异均无统计学意义(P>0.05)。治疗后,2组SOD含量均较治疗前升高(P<0.05),LPO含量均较治疗前降低(P<0.05),研究组SOD含量高于对照组(P<0.05),LPO含量低于对照组(P<0.05)。结论:重用黄芪自拟方联合奥拉西坦胶囊能够改善脑卒中后痴呆患者的痴呆症状、认知功能和记忆功能,临床疗效显著。

Objective： To observe the effect of self- made fang with high dose of astragali combined with Oxiracetam capsules on higher brain functions of patients with dementia after stroke. Methods：Ninety- two cases of patients with dementia after stroke were divided into the research group and the control group randomly, 46 cases in each group. The Oxiracetam capsules therapy was given to both groups and the research group received additional treatment of self- made fang with high dose of astragali. Compared the clinical effect of two groups, evaluated dementia degree, cognitive function and memory function condition before and after treatment in two groups,detected the level of plasma lipid peroxide（LPO） and superoxide dismutase（SOD）. Results：The total effective rate of the research group was 89.13%,and was higher than that of 68.57% in the control group（P〈0.05）. Before treatment,comparing the scores of Hasegawa＇s dementia scale（HDS）,Mini- mental state examination（MMSE） and Wechsler Memory Scale（WMS） in two groups, difference was not significant（P〉 0.05）. After treatment,the scores of HDS,MMSE and WMS were all increased in both groups（P〈0.05）,and each score in the research group was higher than that in the control group（P〈0.05）. Before treatment,the levels of SOD and LPO were lower in both groups,differences being not significant（P〈0.05）. After treatment,the levels of SOD were increased（P〈0.05）,and levels of LPO were declined（P〈0.05） in both groups（P〈0.05 compared with before treatment）. The levels of SOD in the research group was higher than those in the control group, and the levels of LPO were lower than those in the control group（P 〈0.05）.Conclusion：The treatment of self- made with high dose of astragali combined with Oxiracetam capsules can improve cognitive function and memory function of patients with dementia after stroke,and its clinical effect are effective.