中心静脉导管相关感染的病原菌分布及耐药性分析

Analysis on distribution and drug resistance of pathogens causing central venous catheter-related infections

目的了解临床中心静脉导管相关感染的病原菌分布及耐药情况,为临床治疗提供参考。方法回顾性分析从2011年1月至2015年6月送检的中心静脉导管标本的细菌分布及耐药性。结果送检的731例中心静脉导管标本中,中心静脉导管相关感染共38例,阳性率为5.3%,革兰阳性球菌占分离菌的26.3%,其中主要是表皮葡萄球菌,占13.2%,且均为耐甲氧西林表皮葡萄球菌,未检出耐甲氧西林金黄色葡萄球菌和耐万古霉素的葡萄球菌。革兰阴性杆菌占分离菌的73.7%,主要为鲍曼不动杆菌,约占42.1%。鲍曼不动杆菌最敏感的是阿米卡星,敏感率为87.5%。结论鲍曼不动杆菌是中心静脉导管相关感染中最常见的病原菌,且耐药严重,因此在临床工作中应规范操作,控制感染。

Objective To understand the distribution and drug resistance of pathogens causing catheter related bloodstream infection（CRBSI）to provide reference for clinical treatment.Methods The distribution and drug resistance of pathogens isolated from the central venous catheter from January 2011 to June 2015 were retrospectively analyzed.Results Among 731 submitted samples,38 cases were CRBSI,with the positive rate of 5.3%,in which,the Gram-positive cocci accouted for 26.3% of isolated bacteria and dominated by Staphylococcus epidermidis（13.2%）,moreover which was MRSE.MRSA and VRE were not detected.Gram-negative bacilli accounted for 73.7% of isolated bacteria and dominated by Acinetobacter baumannii（42.1%）,which was most sensitive to amikacin with the sensitivity rate of 87.5%.Conclusion Acinetobacter baumannii is most common pathogen in CRBSI with serious drug resistance,therefore the operating should be standardized in clinical work for controlling infection.