2型糖尿病和糖尿病肾病患者相关检验指标的变化趋势

Change tendency of correlative test indexes in patients with type 2 diabetic mellitus and diabetic nephropathy

目的分析2型糖尿病(T2DM)和糖尿病肾病(DN)患者相关检验指标的变化趋势。方法检测167例T2DM患者的尿微量清蛋白(M-Alb)、血糖和肾功能等指标,再将其按尿M-Alb排泄率分为3组(单纯DM组、早期DN组和临床DN组),对结果进行比较和分析。结果单纯DM组患者的年龄小于早期DN组和临床DN组(P<0.05)。尿M-Alb和尿蛋白阳性率以临床DN组最高,3组差异有统计学意义(P<0.05)。单纯DM组和早期DN组之间血糖指标差异不显著,临床DN组显著高于单纯DM组和早期DN组(P<0.05)。单纯DM组尿素(Urea)和肌酐(Cr)水平明显低于早期DN组和临床DN组,3组间差异有统计学意义(P<0.01)。结论 DN越重,患者尿M-Alb、血糖和肾功能指标就越高,尿蛋白和尿糖阳性率也越高,肾功能受损的趋势也越明显。

Objective To analyze the variation tendency of correlative test indexes in the patients with type 2diabetic mellitus（T2DM）and diabetic nephropathy（DN）.Methods The urinary microalbumin（M-Alb）,blood glucose and renal function were determined in 167 cases of T2 DM.Then the cases were divided into the simple DM group,early DN group and clinical DN group according to the excretion rates of urinary M-Alb.The determined results were compared among 3group and analyzed.Results The age in the simple DM group was smaller than that in the early DN group and clinical DN group（P〈0.05）.The positive rates of urinary M-Alb and urinary protein were highest in the clinical DN group,the differences among 3groups had statistical significance（P〈0.05）.The difference of blood glucose indexes had no statistical difference between the simple DM group and early DN group,the clinical DN group was apparently higher than that in the simple DM group and early DN group（P〈0.05）.The levels of urea（Urea）and creatinine（Cr）in the simple DM group were significantly lower than those in the early DN group and clinical DN group,the differences among 3groups had statistical significance（P〈0.01）.Conclusion The severe the DN,the higher the urinary M-Alb,blood glucose and renal function indicators,the higher the positive rates of urinary protein and urinary glucose,the more significant the tendency of renal function damage.