摘要
目的 探讨血小板计数与脾脏长径比值[platelet count(PC)/spleen diameter(SD)ratio,PC/SD ratio]对肝硬化患者食道静脉曲张(esophageal varices,EV)的预测价值。方法 回顾性分析自2010年1月至2014年6月信阳市第四人民医院就诊的肝硬化患者的临床资料。根据患者是否存在食道静脉曲张将患者分为静脉曲张组(EV)和非静脉曲张组(NEV),比较组间患者PC/SD比值的差异。绘制PC/SD比值预测肝硬化患者EV发生情况的ROC曲线,并分析其特异度和敏感度,寻找最佳预测值。结果 本次研究共收集到符合纳入排除标准的肝硬化患者88例,其中EV组71例,NEV组17例,EV组患者血小板计数较低,脾脏长径较大,PC/SD比值较小,组间差异有统计学意义(P〈0.05),PC/SD比值与肝硬化患者食道静脉曲张发生情况的ROC曲线下面积为0.89,95%CI为0.80~0.97,选择1044为截断点,其预测的敏感性和特异性分别为77%和85%。结论 PC/SD比值预测肝硬化EV发生情况具有较好的敏感性和特异性,值得进一步研究。
Objective To investigate the predictive value of Platelet count/spleen diameter ratio (PC/SD ratio) for e- sophageal varices (EV) in patients with liver cirrhosis. Methods The clinical data of patients with liver cirrhosis and admitted in our department from January 2010 to July 2014 were retrospectively collected. Patients were divided into two groups (EV vs. NEV) according to whether esophageal variees occur, and compare the difference of relative indicators between groups. Draw the ROC curve of PC/SD ratio and the occurrence of esophageal varices to analysis its specificity and sensitivity degrees and find the best predictive value. Results Totally 88 cases conformed to the inclusion and ex- clusion criteria were enrolled in this study totally, with 71 of group EV and 17 of group NEV. Compared with NEV, pa- tients of group EV have a fewer platelet count, lager spleen diameter and lower PC/SD ratio, there are significance difference between groups ( P 〈 0. 05 ). The ROC curve of PC/SD ratio and the occurrence of esophageal varices mani- fest that, the area under the curve (AUC) is 0. 89, 95% CI =0. 80 -0. 97; Selected 1044 as the predictive value the specificity and sensitivity are 77% and 85% respectively. Conclusion PC/SD ratio has a preferable specificity and sensitivity in predicting esophageal varices (EV) in patients with liver cirrhosis, which worth luther study.
出处
《医药论坛杂志》
2016年第5期19-21,共3页
Journal of Medical Forum